Influenza infection, SARS, MERS and COVID-19

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Influenza infection, SARS, MERS and COVID-19 : Cytokine storm - The common denominator and the lessons to be learned. / Ryabkova, Varvara A ; Churilov, Leonid P ; Shoenfeld, Yehuda.

In: Clinical Immunology, Vol. 223, 108652, 02.2021.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{8a7c56ae53a24f4da7725f6919f0eb7f,

title = "Influenza infection, SARS, MERS and COVID-19: Cytokine storm - The common denominator and the lessons to be learned",

abstract = "The outbreak of COVID-19 reminds us that the emerging and reemerging respiratory virus infections pose a continuing threat to human life. Cytokine storm syndromes of viral origin seem to have a common pathogenesis of the imbalanced immune response with the exaggerated inflammatory reaction combined with the reduction and functional exhaustion of T cells. Immunomodulatory therapy is gaining interest in COVID-19, but this strategy has received less attention in other respiratory viral infections than it deserved. In this review we suggest that based on the similarities of the immune dysfunction in the severe cases of different respiratory viral infections, some lessons from the immunomodulatory therapy of COVID-19 (particularly regarding the choice of an immunomodulatory drug, the selection of patients and optimal time window for this kind of therapy) could be applied for some cases of severe influenza infection and probably for some future outbreaks of novel severe respiratory viral infections.",

keywords = "COVID-19, Cytokine storm, IL-6, Immunotherapy, Influenza, SARS, Immunotherapy/methods, Immunomodulation, Humans, COVID-19/immunology, Inflammation, Influenza, Human/immunology, SARS Virus/physiology, Severe Acute Respiratory Syndrome/immunology, Orthomyxoviridae/physiology, SARS-CoV-2/physiology, Cytokine Release Syndrome/immunology, Middle East Respiratory Syndrome Coronavirus/physiology, Cytokines/metabolism, Coronavirus Infections/immunology, MORTALITY, SURVIVAL, INFLAMMATORY RESPONSE SYNDROME, THERAPY, DYSFUNCTION, T-CELLS, VIRUS-INFECTION, RESPIRATORY-DISTRESS-SYNDROME, HAMMAN-RICH SYNDROME, BLOCKADE",

author = "Ryabkova, {Varvara A} and Churilov, {Leonid P} and Yehuda Shoenfeld",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = feb,

doi = "10.1016/j.clim.2020.108652",

language = "English",

volume = "223",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Influenza infection, SARS, MERS and COVID-19

T2 - Cytokine storm - The common denominator and the lessons to be learned

AU - Ryabkova, Varvara A

AU - Churilov, Leonid P

AU - Shoenfeld, Yehuda

PY - 2021/2

Y1 - 2021/2

N2 - The outbreak of COVID-19 reminds us that the emerging and reemerging respiratory virus infections pose a continuing threat to human life. Cytokine storm syndromes of viral origin seem to have a common pathogenesis of the imbalanced immune response with the exaggerated inflammatory reaction combined with the reduction and functional exhaustion of T cells. Immunomodulatory therapy is gaining interest in COVID-19, but this strategy has received less attention in other respiratory viral infections than it deserved. In this review we suggest that based on the similarities of the immune dysfunction in the severe cases of different respiratory viral infections, some lessons from the immunomodulatory therapy of COVID-19 (particularly regarding the choice of an immunomodulatory drug, the selection of patients and optimal time window for this kind of therapy) could be applied for some cases of severe influenza infection and probably for some future outbreaks of novel severe respiratory viral infections.

AB - The outbreak of COVID-19 reminds us that the emerging and reemerging respiratory virus infections pose a continuing threat to human life. Cytokine storm syndromes of viral origin seem to have a common pathogenesis of the imbalanced immune response with the exaggerated inflammatory reaction combined with the reduction and functional exhaustion of T cells. Immunomodulatory therapy is gaining interest in COVID-19, but this strategy has received less attention in other respiratory viral infections than it deserved. In this review we suggest that based on the similarities of the immune dysfunction in the severe cases of different respiratory viral infections, some lessons from the immunomodulatory therapy of COVID-19 (particularly regarding the choice of an immunomodulatory drug, the selection of patients and optimal time window for this kind of therapy) could be applied for some cases of severe influenza infection and probably for some future outbreaks of novel severe respiratory viral infections.

KW - COVID-19

KW - Cytokine storm

KW - IL-6

KW - Immunotherapy

KW - Influenza

KW - SARS

KW - Immunotherapy/methods

KW - Immunomodulation

KW - Humans

KW - COVID-19/immunology

KW - Inflammation

KW - Influenza, Human/immunology

KW - SARS Virus/physiology

KW - Severe Acute Respiratory Syndrome/immunology

KW - Orthomyxoviridae/physiology

KW - SARS-CoV-2/physiology

KW - Cytokine Release Syndrome/immunology

KW - Middle East Respiratory Syndrome Coronavirus/physiology

KW - Cytokines/metabolism

KW - Coronavirus Infections/immunology

KW - MORTALITY

KW - SURVIVAL

KW - INFLAMMATORY RESPONSE SYNDROME

KW - THERAPY

KW - DYSFUNCTION

KW - T-CELLS

KW - VIRUS-INFECTION

KW - RESPIRATORY-DISTRESS-SYNDROME

KW - HAMMAN-RICH SYNDROME

KW - BLOCKADE

UR - http://www.scopus.com/inward/record.url?scp=85098698854&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/76722ea5-b2b8-3d6f-bfe8-9fd3fab2420a/

U2 - 10.1016/j.clim.2020.108652

DO - 10.1016/j.clim.2020.108652

M3 - Review article

C2 - 33333256

VL - 223

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

M1 - 108652

ER -

ID: 71999492

Influenza infection, SARS, MERS and COVID-19: Cytokine storm - The common denominator and the lessons to be learned

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