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Influence of inactivation of the m-protein gene on antitumor activity of live streptococcus pyogenes in experiment. / Suvorova, M. A.; Kramskaya, T. A.; Duplik, N. V.; Chereshnev, V. A.; Grabovskaya, K. B.; Ermolenko, E. I.; Suvorov, A. N.; Kiseleva, E. P.

In: Voprosy Onkologii, Vol. 63, No. 5, 2017, p. 802-806.

Research output: Contribution to journal › Article › peer-review

Harvard

Suvorova, MA, Kramskaya, TA, Duplik, NV, Chereshnev, VA, Grabovskaya, KB, Ermolenko, EI, Suvorov, AN & Kiseleva, EP 2017, 'Influence of inactivation of the m-protein gene on antitumor activity of live streptococcus pyogenes in experiment', Voprosy Onkologii, vol. 63, no. 5, pp. 802-806.

APA

Suvorova, M. A., Kramskaya, T. A., Duplik, N. V., Chereshnev, V. A., Grabovskaya, K. B., Ermolenko, E. I., Suvorov, A. N., & Kiseleva, E. P. (2017). Influence of inactivation of the m-protein gene on antitumor activity of live streptococcus pyogenes in experiment. Voprosy Onkologii, 63(5), 802-806.

Vancouver

Suvorova MA, Kramskaya TA, Duplik NV, Chereshnev VA, Grabovskaya KB, Ermolenko EI et al. Influence of inactivation of the m-protein gene on antitumor activity of live streptococcus pyogenes in experiment. Voprosy Onkologii. 2017;63(5):802-806.

Author

Suvorova, M. A. ; Kramskaya, T. A. ; Duplik, N. V. ; Chereshnev, V. A. ; Grabovskaya, K. B. ; Ermolenko, E. I. ; Suvorov, A. N. ; Kiseleva, E. P. / Influence of inactivation of the m-protein gene on antitumor activity of live streptococcus pyogenes in experiment. In: Voprosy Onkologii. 2017 ; Vol. 63, No. 5. pp. 802-806.

BibTeX

@article{9902db49839c4d6db0aca8f1876902a7,
title = "Influence of inactivation of the m-protein gene on antitumor activity of live streptococcus pyogenes in experiment",
abstract = "There was investigated a new recombinant strain of Streptococcus pyogenes serotype M39, which did not express M-protein - {"}Gurov{"} emrrr. It revealed a higher antitumor activity towards transplantable solid murine tumors compared to wild type {"}Gurov{"}. In a model of sygeneic transplantable hepatoma 22a we observed retardation of tumor growth and increase of survival after twice intratumoral injections of live S. pyogenes {"}Gurov{"} emm∼ as compared to a group of mice that received injections of S. pyogenes {"}Gurov{"} as well as to a control group of mice without treatment. In a model of transplantable Sarcoma 37 we also observed retardation of tumor growth after the introduction of mutant strain but without positive effect on survival. Additionally, it was showed that {"}Gurov{"} emm∼ strain possessed a higher direct cytotoxic effect towards hepatoma 22a cell line in vitro as compared to wild type {"}Gurov{"}. Genetic modification of S. pyogenes {"}Gurov{"} strain attenuated its virulence and allowed to consider this strain as potent candidate for further studies and its possible application for oncolytic therapy in the future.",
keywords = "Hepatoma 22a, M-protein, Sarcoma 37, Streptococcus pyogenes, Transplantable tumors",
author = "Suvorova, {M. A.} and Kramskaya, {T. A.} and Duplik, {N. V.} and Chereshnev, {V. A.} and Grabovskaya, {K. B.} and Ermolenko, {E. I.} and Suvorov, {A. N.} and Kiseleva, {E. P.}",
year = "2017",
language = "русский",
volume = "63",
pages = "802--806",
journal = "Вопросы онкологии",
issn = "0507-3758",
publisher = "Медицина",
number = "5",

}

RIS

TY - JOUR

T1 - Influence of inactivation of the m-protein gene on antitumor activity of live streptococcus pyogenes in experiment

AU - Suvorova, M. A.

AU - Kramskaya, T. A.

AU - Duplik, N. V.

AU - Chereshnev, V. A.

AU - Grabovskaya, K. B.

AU - Ermolenko, E. I.

AU - Suvorov, A. N.

AU - Kiseleva, E. P.

PY - 2017

Y1 - 2017

N2 - There was investigated a new recombinant strain of Streptococcus pyogenes serotype M39, which did not express M-protein - "Gurov" emrrr. It revealed a higher antitumor activity towards transplantable solid murine tumors compared to wild type "Gurov". In a model of sygeneic transplantable hepatoma 22a we observed retardation of tumor growth and increase of survival after twice intratumoral injections of live S. pyogenes "Gurov" emm∼ as compared to a group of mice that received injections of S. pyogenes "Gurov" as well as to a control group of mice without treatment. In a model of transplantable Sarcoma 37 we also observed retardation of tumor growth after the introduction of mutant strain but without positive effect on survival. Additionally, it was showed that "Gurov" emm∼ strain possessed a higher direct cytotoxic effect towards hepatoma 22a cell line in vitro as compared to wild type "Gurov". Genetic modification of S. pyogenes "Gurov" strain attenuated its virulence and allowed to consider this strain as potent candidate for further studies and its possible application for oncolytic therapy in the future.

AB - There was investigated a new recombinant strain of Streptococcus pyogenes serotype M39, which did not express M-protein - "Gurov" emrrr. It revealed a higher antitumor activity towards transplantable solid murine tumors compared to wild type "Gurov". In a model of sygeneic transplantable hepatoma 22a we observed retardation of tumor growth and increase of survival after twice intratumoral injections of live S. pyogenes "Gurov" emm∼ as compared to a group of mice that received injections of S. pyogenes "Gurov" as well as to a control group of mice without treatment. In a model of transplantable Sarcoma 37 we also observed retardation of tumor growth after the introduction of mutant strain but without positive effect on survival. Additionally, it was showed that "Gurov" emm∼ strain possessed a higher direct cytotoxic effect towards hepatoma 22a cell line in vitro as compared to wild type "Gurov". Genetic modification of S. pyogenes "Gurov" strain attenuated its virulence and allowed to consider this strain as potent candidate for further studies and its possible application for oncolytic therapy in the future.

KW - Hepatoma 22a

KW - M-protein

KW - Sarcoma 37

KW - Streptococcus pyogenes

KW - Transplantable tumors

UR - http://www.scopus.com/inward/record.url?scp=85040540543&partnerID=8YFLogxK

M3 - статья

AN - SCOPUS:85040540543

VL - 63

SP - 802

EP - 806

JO - Вопросы онкологии

JF - Вопросы онкологии

SN - 0507-3758

IS - 5

ER -

ID: 94444938