Standard

Influence of donor age on cellular ability to carry out DNA repair via homologous recombination. / Bernadotte, A.; Mikhelson, V.M.; Spivak, I.M.; Ryzak, G.A.

In: Advances in Gerontology (Uspekhi Gerontologii), Vol. 4, No. 3, 2014, p. 171-175.

Research output: Contribution to journal › Article › peer-review

Harvard

Bernadotte, A, Mikhelson, VM, Spivak, IM & Ryzak, GA 2014, 'Influence of donor age on cellular ability to carry out DNA repair via homologous recombination', Advances in Gerontology (Uspekhi Gerontologii), vol. 4, no. 3, pp. 171-175. https://doi.org/10.1134/S2079057014030023

APA

Bernadotte, A., Mikhelson, V. M., Spivak, I. M., & Ryzak, G. A. (2014). Influence of donor age on cellular ability to carry out DNA repair via homologous recombination. Advances in Gerontology (Uspekhi Gerontologii), 4(3), 171-175. https://doi.org/10.1134/S2079057014030023

Vancouver

Bernadotte A, Mikhelson VM, Spivak IM, Ryzak GA. Influence of donor age on cellular ability to carry out DNA repair via homologous recombination. Advances in Gerontology (Uspekhi Gerontologii). 2014;4(3):171-175. https://doi.org/10.1134/S2079057014030023

Author

Bernadotte, A. ; Mikhelson, V.M. ; Spivak, I.M. ; Ryzak, G.A. / Influence of donor age on cellular ability to carry out DNA repair via homologous recombination. In: Advances in Gerontology (Uspekhi Gerontologii). 2014 ; Vol. 4, No. 3. pp. 171-175.

BibTeX

@article{6eff4779563044eeabb83613889b6f01,
title = "Influence of donor age on cellular ability to carry out DNA repair via homologous recombination",
abstract = "Cells from old and young donors differ in their abilities for homologous recombination in vitro, which is distinctly visible at the stage of convergence of the homologous chromosomes. We hypothesize that this effect contributes to genome instability and aging. Cells from donors 70 years and older have a limited ability for homologous recombination induced by X-ray irradiation. Interestingly, a repressor of RNA polymerase II, alpha-amanitin, induces homologous recombination when administered at physiologically toxic doses in cells from donors in all age groups, old and young, as well as in cells with genetic defects in the DNA repair system due to mutations in BRCA1 and BRCA2 genes. Furthermore, in BRCA1 and BRCA2 mutant cells, the effects of irradiation and alpha-amanitin damage are not integrated and do not increase the rate of homologous recombination. {\textcopyright} 2014 Pleiades Publishing, Ltd.",
author = "A. Bernadotte and V.M. Mikhelson and I.M. Spivak and G.A. Ryzak",
year = "2014",
doi = "10.1134/S2079057014030023",
language = "English",
volume = "4",
pages = "171--175",
journal = "Advances in Gerontology",
issn = "2079-0570",
publisher = "Springer Nature",
number = "3",

}

RIS

TY - JOUR

T1 - Influence of donor age on cellular ability to carry out DNA repair via homologous recombination

AU - Bernadotte, A.

AU - Mikhelson, V.M.

AU - Spivak, I.M.

AU - Ryzak, G.A.

PY - 2014

Y1 - 2014

N2 - Cells from old and young donors differ in their abilities for homologous recombination in vitro, which is distinctly visible at the stage of convergence of the homologous chromosomes. We hypothesize that this effect contributes to genome instability and aging. Cells from donors 70 years and older have a limited ability for homologous recombination induced by X-ray irradiation. Interestingly, a repressor of RNA polymerase II, alpha-amanitin, induces homologous recombination when administered at physiologically toxic doses in cells from donors in all age groups, old and young, as well as in cells with genetic defects in the DNA repair system due to mutations in BRCA1 and BRCA2 genes. Furthermore, in BRCA1 and BRCA2 mutant cells, the effects of irradiation and alpha-amanitin damage are not integrated and do not increase the rate of homologous recombination. © 2014 Pleiades Publishing, Ltd.

AB - Cells from old and young donors differ in their abilities for homologous recombination in vitro, which is distinctly visible at the stage of convergence of the homologous chromosomes. We hypothesize that this effect contributes to genome instability and aging. Cells from donors 70 years and older have a limited ability for homologous recombination induced by X-ray irradiation. Interestingly, a repressor of RNA polymerase II, alpha-amanitin, induces homologous recombination when administered at physiologically toxic doses in cells from donors in all age groups, old and young, as well as in cells with genetic defects in the DNA repair system due to mutations in BRCA1 and BRCA2 genes. Furthermore, in BRCA1 and BRCA2 mutant cells, the effects of irradiation and alpha-amanitin damage are not integrated and do not increase the rate of homologous recombination. © 2014 Pleiades Publishing, Ltd.

U2 - 10.1134/S2079057014030023

DO - 10.1134/S2079057014030023

M3 - Article

VL - 4

SP - 171

EP - 175

JO - Advances in Gerontology

JF - Advances in Gerontology

SN - 2079-0570

IS - 3

ER -

ID: 5751474