Research output: Contribution to journal › Review article › peer-review
Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease. / Дворникова, Кристина Алексеевна; Платонова, Ольга Николаевна; Быстрова, Елена Юрьевна.
In: International Journal of Molecular Sciences, Vol. 24, No. 12, 9937, 09.06.2023.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease
AU - Дворникова, Кристина Алексеевна
AU - Платонова, Ольга Николаевна
AU - Быстрова, Елена Юрьевна
PY - 2023/6/9
Y1 - 2023/6/9
N2 - Inflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public health concern. It is generally acknowledged that a variety of factors play a role in the pathogenesis of this group of chronic inflammatory diseases. The diversity of molecular actors involved in IBD does not allow us to fully assess the causal relationships existing in such interactions. Given the high immunomodulatory activity of histamine and the complex immune-mediated nature of inflammatory bowel disease, the role of histamine and its receptors in the gut may be significant. This paper has been prepared to provide a schematic of the most important and possible molecular signaling pathways related to histamine and its receptors and to assess their relevance for the development of therapeutic approaches.
AB - Inflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public health concern. It is generally acknowledged that a variety of factors play a role in the pathogenesis of this group of chronic inflammatory diseases. The diversity of molecular actors involved in IBD does not allow us to fully assess the causal relationships existing in such interactions. Given the high immunomodulatory activity of histamine and the complex immune-mediated nature of inflammatory bowel disease, the role of histamine and its receptors in the gut may be significant. This paper has been prepared to provide a schematic of the most important and possible molecular signaling pathways related to histamine and its receptors and to assess their relevance for the development of therapeutic approaches.
KW - Cell Physiological Phenomena
KW - Colitis, Ulcerative/metabolism
KW - Histamine
KW - Humans
KW - Inflammatory Bowel Diseases/metabolism
UR - https://www.mendeley.com/catalogue/9f9ed8bf-64d0-3b5d-b7f7-12662d4dadec/
U2 - 10.3390/ijms24129937
DO - 10.3390/ijms24129937
M3 - Review article
C2 - 37373085
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1422-0067
IS - 12
M1 - 9937
ER -
ID: 108770013