Research output: Contribution to journal › Article › peer-review
In vitro derivation and characterization of a colorectal cancer stem cell subpopulation. / Davydov-Sinitsyn, A.P.; Bazhenova, O.V.; Liskovykh, M.A.; Chechik, L.L.; Ponomartsev, S.V.; Tomilin, A.N.; Tolkunova, E.N.
In: Cell and Tissue Biology, No. 5, 2013, p. 318-323.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - In vitro derivation and characterization of a colorectal cancer stem cell subpopulation
AU - Davydov-Sinitsyn, A.P.
AU - Bazhenova, O.V.
AU - Liskovykh, M.A.
AU - Chechik, L.L.
AU - Ponomartsev, S.V.
AU - Tomilin, A.N.
AU - Tolkunova, E.N.
PY - 2013
Y1 - 2013
N2 - In present publication we describe for the first time the obtainment of cancer stem cells from a weakly metastatic human colorectal carcinoma cell line MIP101 via selecting from the native population the cells that express intensively an embryonic stem cell marker, POU5F1 (Oct4). We provide the evidence that these cells possess an elevated clonogenic and tumorigenic potential when compared to the native population, and this correlates to the hypothesis of cancer stem cells' primary role in the development of malignant neoplasms.
AB - In present publication we describe for the first time the obtainment of cancer stem cells from a weakly metastatic human colorectal carcinoma cell line MIP101 via selecting from the native population the cells that express intensively an embryonic stem cell marker, POU5F1 (Oct4). We provide the evidence that these cells possess an elevated clonogenic and tumorigenic potential when compared to the native population, and this correlates to the hypothesis of cancer stem cells' primary role in the development of malignant neoplasms.
U2 - 10.1134/S1990519X13040044
DO - 10.1134/S1990519X13040044
M3 - статья
SP - 318
EP - 323
JO - Cell and Tissue Biology
JF - Cell and Tissue Biology
SN - 1990-519X
IS - 5
ER -
ID: 7411682