Standard

In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. / Fraune, Sebastian; Augustin, René; Anton-Erxleben, Friederike; Wittlieb, Jörg; Gelhaus, Christoph; Klimovich, Vladimir B.; Samoilovich, Marina P.; Bosch, Thomas C.G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 42, 19.10.2010, p. 18067-18072.

Research output: Contribution to journal › Article › peer-review

Harvard

Fraune, S, Augustin, R, Anton-Erxleben, F, Wittlieb, J, Gelhaus, C, Klimovich, VB, Samoilovich, MP & Bosch, TCG 2010, 'In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 42, pp. 18067-18072. https://doi.org/10.1073/pnas.1008573107

APA

Fraune, S., Augustin, R., Anton-Erxleben, F., Wittlieb, J., Gelhaus, C., Klimovich, V. B., Samoilovich, M. P., & Bosch, T. C. G. (2010). In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. Proceedings of the National Academy of Sciences of the United States of America, 107(42), 18067-18072. https://doi.org/10.1073/pnas.1008573107

Vancouver

Fraune S, Augustin R, Anton-Erxleben F, Wittlieb J, Gelhaus C, Klimovich VB et al. In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. Proceedings of the National Academy of Sciences of the United States of America. 2010 Oct 19;107(42):18067-18072. https://doi.org/10.1073/pnas.1008573107

Author

Fraune, Sebastian ; Augustin, René ; Anton-Erxleben, Friederike ; Wittlieb, Jörg ; Gelhaus, Christoph ; Klimovich, Vladimir B. ; Samoilovich, Marina P. ; Bosch, Thomas C.G. / In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. In: Proceedings of the National Academy of Sciences of the United States of America. 2010 ; Vol. 107, No. 42. pp. 18067-18072.

BibTeX

@article{4a78f69b6c72430e8a7ed7bb34880068,
title = "In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides",
abstract = "Early embryos of many organisms develop outside the mother and are immediately confronted with myriads of potential colonizers. How these naive developmental stages control and shape the bacterial colonization is largely unknown. Here we show that early embryonic stages of the basal metazoan Hydra are able to control bacterial colonization by using maternal antimicrobial peptides. Antimicrobial peptides of the periculin family selecting for a specific bacterial colonization during embryogenesis are produced in the oocyte and in early embryos. If overexpressed in hydra ectodermal epithelial cells, periculin1a drastically reduces the bacterial load, indicating potent antimicrobial activity. Unexpectedly, transgenic polyps also revealed that periculin, in addition to bactericidal activity, changes the structure of the bacterial community. These findings delineate a role for antimicrobial peptides both in selecting particular bacterial partners during development and as important components of a {"}be prepared{"} strategy providing transgenerational protection.",
keywords = "Cnidaria, Embryo protection, Host-microbe interaction, Hydra, Innate immunity",
author = "Sebastian Fraune and Ren{\'e} Augustin and Friederike Anton-Erxleben and J{\"o}rg Wittlieb and Christoph Gelhaus and Klimovich, {Vladimir B.} and Samoilovich, {Marina P.} and Bosch, {Thomas C.G.}",
year = "2010",
month = oct,
day = "19",
doi = "10.1073/pnas.1008573107",
language = "English",
volume = "107",
pages = "18067--18072",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "42",

}

RIS

TY - JOUR

T1 - In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides

AU - Fraune, Sebastian

AU - Augustin, René

AU - Anton-Erxleben, Friederike

AU - Wittlieb, Jörg

AU - Gelhaus, Christoph

AU - Klimovich, Vladimir B.

AU - Samoilovich, Marina P.

AU - Bosch, Thomas C.G.

PY - 2010/10/19

Y1 - 2010/10/19

N2 - Early embryos of many organisms develop outside the mother and are immediately confronted with myriads of potential colonizers. How these naive developmental stages control and shape the bacterial colonization is largely unknown. Here we show that early embryonic stages of the basal metazoan Hydra are able to control bacterial colonization by using maternal antimicrobial peptides. Antimicrobial peptides of the periculin family selecting for a specific bacterial colonization during embryogenesis are produced in the oocyte and in early embryos. If overexpressed in hydra ectodermal epithelial cells, periculin1a drastically reduces the bacterial load, indicating potent antimicrobial activity. Unexpectedly, transgenic polyps also revealed that periculin, in addition to bactericidal activity, changes the structure of the bacterial community. These findings delineate a role for antimicrobial peptides both in selecting particular bacterial partners during development and as important components of a "be prepared" strategy providing transgenerational protection.

AB - Early embryos of many organisms develop outside the mother and are immediately confronted with myriads of potential colonizers. How these naive developmental stages control and shape the bacterial colonization is largely unknown. Here we show that early embryonic stages of the basal metazoan Hydra are able to control bacterial colonization by using maternal antimicrobial peptides. Antimicrobial peptides of the periculin family selecting for a specific bacterial colonization during embryogenesis are produced in the oocyte and in early embryos. If overexpressed in hydra ectodermal epithelial cells, periculin1a drastically reduces the bacterial load, indicating potent antimicrobial activity. Unexpectedly, transgenic polyps also revealed that periculin, in addition to bactericidal activity, changes the structure of the bacterial community. These findings delineate a role for antimicrobial peptides both in selecting particular bacterial partners during development and as important components of a "be prepared" strategy providing transgenerational protection.

KW - Cnidaria

KW - Embryo protection

KW - Host-microbe interaction

KW - Hydra

KW - Innate immunity

UR - http://www.scopus.com/inward/record.url?scp=78149248987&partnerID=8YFLogxK

U2 - 10.1073/pnas.1008573107

DO - 10.1073/pnas.1008573107

M3 - Article

C2 - 20921390

AN - SCOPUS:78149248987

VL - 107

SP - 18067

EP - 18072

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 42

ER -

ID: 89784721