TY - JOUR

T1 - Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice

AU - Maggi, Silvia

AU - Bon, Carlotta

AU - Gustincich, Stefano

AU - Tucci, Valter

AU - Gainetdinov, Raul R.

AU - Espinoza, Stefano

N1 - Maggi, S., Bon, C., Gustincich, S. et al. Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice. Sci Rep 12, 14708 (2022). https://doi.org/10.1038/s41598-022-18924-z

PY - 2022

Y1 - 2022

N2 - Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain serotonin functions and emotional behaviours. However, most of its functions remain undiscovered. Given the role of serotonin and limbic regions in some aspects of cognition, we used a temporal decision-making task to unveil a possible role of TAAR5 in cognitive processes. We found that TAAR5 knock-out mice showed a generally better performance due to a reduced number of errors and displayed a greater rate of improvement at the task than WT littermates. However, task-related parameters, such as time accuracy and uncertainty have not changed significantly. Overall, we show that TAAR5 modulates specific domains of cognition, highlighting a new role in brain physiology.

AB - Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain serotonin functions and emotional behaviours. However, most of its functions remain undiscovered. Given the role of serotonin and limbic regions in some aspects of cognition, we used a temporal decision-making task to unveil a possible role of TAAR5 in cognitive processes. We found that TAAR5 knock-out mice showed a generally better performance due to a reduced number of errors and displayed a greater rate of improvement at the task than WT littermates. However, task-related parameters, such as time accuracy and uncertainty have not changed significantly. Overall, we show that TAAR5 modulates specific domains of cognition, highlighting a new role in brain physiology.

KW - Cognitive neuroscience

KW - neuroscience

U2 - https://doi.org/10.1038/s41598-022-18924-z

DO - https://doi.org/10.1038/s41598-022-18924-z

M3 - Article

VL - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 14708

ER -