Impact of platelet phenotype on myocardial infarction. / Gabbasov, Zufar; Sabo, Jan; Petrovic, Daniel; Martell-Claros, Nieves; Zagatina, Angela; Mrdovic, Igor; Ciccocioppo, Rachele; Cangemi, Giuseppina Cristina; Klimas, Jan; Kruzliak, Peter.
In: Biomarkers, Vol. 20, No. 1, 01.02.2015, p. 17-25.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Impact of platelet phenotype on myocardial infarction
AU - Gabbasov, Zufar
AU - Sabo, Jan
AU - Petrovic, Daniel
AU - Martell-Claros, Nieves
AU - Zagatina, Angela
AU - Mrdovic, Igor
AU - Ciccocioppo, Rachele
AU - Cangemi, Giuseppina Cristina
AU - Klimas, Jan
AU - Kruzliak, Peter
PY - 2015/2/1
Y1 - 2015/2/1
N2 - In acute myocardial infarction patients the injured vascular wall triggers thrombus formation in the damage site. Fibrin fibers and blood cellular elements are the major components of thrombus formed in acute occlusion of coronary arteries. It has been established that the initial thrombus is primarily composed of activated platelets rapidly stabilized by fibrin fibers. This review highlights the role of platelet membrane phenotype in pathophysiology of myocardial infarction. Here, we regard platelet phenotype as quantitative and qualitative parameters of the plasma membrane outer surface, which are crucial for platelet participation in blood coagulation, development of local inflammation and tissue repair.
AB - In acute myocardial infarction patients the injured vascular wall triggers thrombus formation in the damage site. Fibrin fibers and blood cellular elements are the major components of thrombus formed in acute occlusion of coronary arteries. It has been established that the initial thrombus is primarily composed of activated platelets rapidly stabilized by fibrin fibers. This review highlights the role of platelet membrane phenotype in pathophysiology of myocardial infarction. Here, we regard platelet phenotype as quantitative and qualitative parameters of the plasma membrane outer surface, which are crucial for platelet participation in blood coagulation, development of local inflammation and tissue repair.
KW - Acute coronary syndrome
KW - Cardiovascular risk
KW - Myocardial infarction
KW - Platelet phenotype
KW - Platelets
UR - http://www.scopus.com/inward/record.url?scp=84921813366&partnerID=8YFLogxK
U2 - 10.3109/1354750X.2014.993707
DO - 10.3109/1354750X.2014.993707
M3 - Review article
C2 - 25510672
AN - SCOPUS:84921813366
VL - 20
SP - 17
EP - 25
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 1
ER -
ID: 43613338