Pharmacologically important properties of two structurally related biologically active 1,2,4-thiadiazole derivatives were investigated in phosphate buffer and biorelevant media FaSSIF simulating the intestinal fluid. Solubility and distribution coefficients of thiadiazoles were found to be substantially higher in FaSSIF than in blank buffer. On the contrary, permeability coefficients decreased and dissolution rate was not changed in FaSSIF. Mechanism of FaSSIF components action on thiadiazoles behavior was revealed using 1H NMR and UV-spectroscopy.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalJournal of Molecular Liquids
Volume247
Early online date23 Sep 2017
DOIs
StatePublished - 2017
Externally publishedYes

    Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Materials Chemistry

    Research areas

  • 1,2,4-Thiadiazole, Biorelevant medium, Dissolution, Distribution, Permeability

ID: 37016346