Immunohistochemical assay of cellular cycle markers : An alternative to chip-diagnosis of breast cancer. / Petrov, S. V.; Orlova, R. V.; Raskin, G. A.; Khasanov, R. Sh.
In: Voprosy Onkologii, Vol. 53, No. 5, 2007, p. 526-530.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Immunohistochemical assay of cellular cycle markers
T2 - An alternative to chip-diagnosis of breast cancer
AU - Petrov, S. V.
AU - Orlova, R. V.
AU - Raskin, G. A.
AU - Khasanov, R. Sh
PY - 2007
Y1 - 2007
N2 - A new method of evaluation of immunohistochemical markers of cellular cycle (K-67, topoisomerase-11-α, P21/wafl), adhesion molecules (E-cadherin, CD33v6), oncoprotein HER-2, and estrogen and progesterone receptors of tumor is presented. High-precision count of tumor cells, which express each marker, was carried out using serial paraffin sections and Leica CTR5000 morphometric station and Leica Quin Plus program, to identify tumor sensitivity to anthracyclines and taxanes. Proliferative potential, tumor sensitivity to key chemical drugs and prognosis were evaluated on the basis of the evidence obtained and, in particular, the role of the proteins under study played in cellular cycle.
AB - A new method of evaluation of immunohistochemical markers of cellular cycle (K-67, topoisomerase-11-α, P21/wafl), adhesion molecules (E-cadherin, CD33v6), oncoprotein HER-2, and estrogen and progesterone receptors of tumor is presented. High-precision count of tumor cells, which express each marker, was carried out using serial paraffin sections and Leica CTR5000 morphometric station and Leica Quin Plus program, to identify tumor sensitivity to anthracyclines and taxanes. Proliferative potential, tumor sensitivity to key chemical drugs and prognosis were evaluated on the basis of the evidence obtained and, in particular, the role of the proteins under study played in cellular cycle.
UR - http://www.scopus.com/inward/record.url?scp=36549016090&partnerID=8YFLogxK
M3 - Article
C2 - 18154114
AN - SCOPUS:36549016090
VL - 53
SP - 526
EP - 530
JO - Вопросы онкологии
JF - Вопросы онкологии
SN - 0507-3758
IS - 5
ER -
ID: 88358280