For treatment of metastatic lung lesions there was used the method of isolated chemoperfusion in combination with metastasectomy. The study included 74 patients (mean age 43 ± 13,4 years). There were performed 99 normothermic isolated chemoperfusions of the lung: with melphalan (39) and cisplatin (60). During surgery there were no lethality outcomes. In the immediate postoperative period it was recorded 1 (1.4%) death developed in 3 days after surgery. The cause of this death was postperfusion lung edema accompanied by increase of signs of respiratory insufficiency. There were following complications after isolated chemoperfusions of the lung: anemia - 23 (23.1%), nausea - 13 (13.1%), vomiting - 5 (5.1%), atrial fibrillation - 10 (10.1%), pneumonia - 2 (2.0%), pulmonary infarction - 2 (2.0%), chylothorax - 1 (1.0%), pneumothorax - 29 (29,3%), emphysema of soft tissues of the chest wall 73 (73,7%). Thus isolated chemoperfusion of the lung with melphalan or cisplatin is a procedure reproducible and relatively safe.