The airborne magnetic data is considered as one of the best methods to delineate the depth to basement layer. The airborne magnetic survey data obtained from the Egyptian Nuclear Materials Authority. Data is accurately processed, interpreted. Two-dimensional (2D) modeling was performed by GM-SYS, along one selected profile yielded from RTP map. In addition to that, three-dimensional (3D) Euler Deconvolution method was performed to delineate the depth to basement layer. Euler solutions were applied on RTP Grid by structural indexes 0, 1, 2, and 3 to select the best solution. The sedimentary succession of the study area is created using seismic data and well data. Petroleum system model was established to predict the locations of hydrocarbons within the study area. The results of PetroMod confirmed that the area is very promising for hydrocarbon aggregations, and also new hydrocarbon aggregations have been discovered.