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Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways. / Дворникова, Кристина Алексеевна; Платонова, Ольга Николаевна; Быстрова, Елена Юрьевна.

In: International Journal of Molecular Sciences, Vol. 24, No. 3, 2425, 26.01.2023.

Research output: Contribution to journal › Review article › peer-review

Harvard

Дворникова, КА, Платонова, ОН & Быстрова, ЕЮ 2023, 'Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways', International Journal of Molecular Sciences, vol. 24, no. 3, 2425. https://doi.org/10.3390/ijms24032425

APA

Дворникова, К. А., Платонова, О. Н., & Быстрова, Е. Ю. (2023). Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways. International Journal of Molecular Sciences, 24(3), [2425]. https://doi.org/10.3390/ijms24032425

Vancouver

Дворникова КА, Платонова ОН, Быстрова ЕЮ. Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways. International Journal of Molecular Sciences. 2023 Jan 26;24(3). 2425. https://doi.org/10.3390/ijms24032425

Author

Дворникова, Кристина Алексеевна ; Платонова, Ольга Николаевна ; Быстрова, Елена Юрьевна. / Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways. In: International Journal of Molecular Sciences. 2023 ; Vol. 24, No. 3.

BibTeX

@article{e79ec6547e15436c87104728fabbc913,
title = "Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways",
abstract = "The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the state of hypoxia can be characteristic of both normal and pathological conditions. Hypoxia-inducible factors (HIF) play a key role in mediating the response to hypoxia, and they are tightly regulated by a group of enzymes called HIF prolyl hydroxylases (PHD). In this review, we discuss the involvement of inflammation hypoxia and signaling pathways in the pathogenesis of inflammatory bowel disease (IBD) and elaborate in detail on the role of HIF in multiple immune reactions during intestinal inflammation. We emphasize the critical influence of tissue microenvironment and highlight the existence of overlapping functions and immune responses mediated by the same molecular mechanisms. Finally, we also provide an update on the development of corresponding therapeutic approaches that would be useful for treatment or prophylaxis of inflammatory bowel disease.",
keywords = "Humans, Hypoxia-Inducible Factor 1, alpha Subunit/metabolism, Hypoxia/metabolism, Inflammation/metabolism, Inflammatory Bowel Diseases/metabolism, Intestinal Mucosa/metabolism, Signal Transduction, hypoxia, HIF-2α, HIF-1α, adaptive immunity, inflammatory bowel disease, innate immunity, inflammation, ulcerative colitis, Crohn{\textquoteright}s disease",
author = "Дворникова, {Кристина Алексеевна} and Платонова, {Ольга Николаевна} and Быстрова, {Елена Юрьевна}",
year = "2023",
month = jan,
day = "26",
doi = "10.3390/ijms24032425",
language = "English",
volume = "24",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "MDPI AG",
number = "3",

}

RIS

TY - JOUR

T1 - Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways

AU - Дворникова, Кристина Алексеевна

AU - Платонова, Ольга Николаевна

AU - Быстрова, Елена Юрьевна

PY - 2023/1/26

Y1 - 2023/1/26

N2 - The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the state of hypoxia can be characteristic of both normal and pathological conditions. Hypoxia-inducible factors (HIF) play a key role in mediating the response to hypoxia, and they are tightly regulated by a group of enzymes called HIF prolyl hydroxylases (PHD). In this review, we discuss the involvement of inflammation hypoxia and signaling pathways in the pathogenesis of inflammatory bowel disease (IBD) and elaborate in detail on the role of HIF in multiple immune reactions during intestinal inflammation. We emphasize the critical influence of tissue microenvironment and highlight the existence of overlapping functions and immune responses mediated by the same molecular mechanisms. Finally, we also provide an update on the development of corresponding therapeutic approaches that would be useful for treatment or prophylaxis of inflammatory bowel disease.

AB - The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the state of hypoxia can be characteristic of both normal and pathological conditions. Hypoxia-inducible factors (HIF) play a key role in mediating the response to hypoxia, and they are tightly regulated by a group of enzymes called HIF prolyl hydroxylases (PHD). In this review, we discuss the involvement of inflammation hypoxia and signaling pathways in the pathogenesis of inflammatory bowel disease (IBD) and elaborate in detail on the role of HIF in multiple immune reactions during intestinal inflammation. We emphasize the critical influence of tissue microenvironment and highlight the existence of overlapping functions and immune responses mediated by the same molecular mechanisms. Finally, we also provide an update on the development of corresponding therapeutic approaches that would be useful for treatment or prophylaxis of inflammatory bowel disease.

KW - Humans

KW - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism

KW - Hypoxia/metabolism

KW - Inflammation/metabolism

KW - Inflammatory Bowel Diseases/metabolism

KW - Intestinal Mucosa/metabolism

KW - Signal Transduction

KW - hypoxia

KW - HIF-2α

KW - HIF-1α

KW - adaptive immunity

KW - inflammatory bowel disease

KW - innate immunity

KW - inflammation

KW - ulcerative colitis

KW - Crohn’s disease

UR - https://www.mendeley.com/catalogue/6e52e58b-fbfe-3799-8d31-dd8880eade0a/

U2 - 10.3390/ijms24032425

DO - 10.3390/ijms24032425

M3 - Review article

C2 - 36768744

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 3

M1 - 2425

ER -

ID: 108769932