Research output: Contribution to journal › Article › peer-review
Hydroxylamine as an ammonia equivalent: access to NH-tetrahydroisoquinolonic derivatives from aldoximes by the Castagnoli–Cushman reaction followed by reduction. / Bannykh, Anton V.; Bakulina, Olga Yu; Dar'in, Dmitry V.; Krasavin, Mikhail.
In: Mendeleev Communications , Vol. 29, No. 3, 01.05.2019, p. 337-338.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Hydroxylamine as an ammonia equivalent: access to NH-tetrahydroisoquinolonic derivatives from aldoximes by the Castagnoli–Cushman reaction followed by reduction
AU - Bannykh, Anton V.
AU - Bakulina, Olga Yu
AU - Dar'in, Dmitry V.
AU - Krasavin, Mikhail
PY - 2019/5/1
Y1 - 2019/5/1
N2 - A novel synthetic protocol towards trans-NH-tetrahydroisoquinolonic acid esters is based on the Castagnoli–Cushman reaction between aromatic aldehyde oximes and homophthalic anhydride, followed by esterification and TiCl3-promoted reduction. The scope of the method with respect to the aromatic portion (both electron-rich and electron-deficient) is broader compared to the earlier described approaches, which makes it a suitable synthetic strategy for the structure–activity exploration.
AB - A novel synthetic protocol towards trans-NH-tetrahydroisoquinolonic acid esters is based on the Castagnoli–Cushman reaction between aromatic aldehyde oximes and homophthalic anhydride, followed by esterification and TiCl3-promoted reduction. The scope of the method with respect to the aromatic portion (both electron-rich and electron-deficient) is broader compared to the earlier described approaches, which makes it a suitable synthetic strategy for the structure–activity exploration.
KW - CYCLOADDITION
UR - http://www.scopus.com/inward/record.url?scp=85066877174&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/hydroxylamine-ammonia-equivalent-access-nhtetrahydroisoquinolonic-derivatives-aldoximes-castagnolicu
U2 - 10.1016/j.mencom.2019.05.033
DO - 10.1016/j.mencom.2019.05.033
M3 - Article
AN - SCOPUS:85066877174
VL - 29
SP - 337
EP - 338
JO - Mendeleev Communications
JF - Mendeleev Communications
SN - 0959-9436
IS - 3
ER -
ID: 46204154