The content of human physiology as an independent part of modern physiology is discussed. It is substantiated that not only special sections of physiology where functions are specific for humans (the physiology of intellectual activity, speech, labor, and sport), but also the characteristics of functions and the specificity of regulation of each of the physiological systems are subjects of human physiology. The boundaries of the norm, the characteristics of regulation in humans, new chapters of renal physiology that appeared due to the achievements of molecular physiology and require fundamentally new approaches are exemplified by the physiology of the kidneys and water-electrolyte balance. © 2010 Pleiades Publishing, Ltd.