Research output: Contribution to journal › Article › peer-review
Human antimicrobial peptides in autoimmunity. / Umnyakova, Ekaterina S.; Zharkova, Maria S.; Berlov, Mikhail N.; Shamova, Olga V.; Kokryakov, Vladimir N.
In: Autoimmunity, Vol. 53, No. 3, 02.04.2020, p. 137-147.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Human antimicrobial peptides in autoimmunity
AU - Umnyakova, Ekaterina S.
AU - Zharkova, Maria S.
AU - Berlov, Mikhail N.
AU - Shamova, Olga V.
AU - Kokryakov, Vladimir N.
PY - 2020/4/2
Y1 - 2020/4/2
N2 - Antimicrobial peptides (AMPs) were firstly discovered as cytotoxic substances that killed bacteria. Later they were described as biologically active peptides that are able not only to kill invaders but also to modulate host immunity. In particular, it is shown that human antimicrobial peptides are able to influence the activity of different innate and adaptive immunity components, thus, obviously, they also participate in autoimmune processes. In this review we discuss the nature of human AMPs and analyze their role in such autoimmune disorders like type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, Crohn’s disease and sarcoidosis. These peptides were shown to have a “double-sided” influence on the autoimmune disease pathogenesis. Thus, described facts should be taken into account for the development of new pharmaceutical agents to cure patients with autoimmune disorders. These agents could derive from natural antimicrobial peptides that in some cases modulate immune response. For example, it was shown that human AMPs are able to modulate complement system dysregulation of which is known to be one of the most dangerous pathogenic factors during autoimmune processes.
AB - Antimicrobial peptides (AMPs) were firstly discovered as cytotoxic substances that killed bacteria. Later they were described as biologically active peptides that are able not only to kill invaders but also to modulate host immunity. In particular, it is shown that human antimicrobial peptides are able to influence the activity of different innate and adaptive immunity components, thus, obviously, they also participate in autoimmune processes. In this review we discuss the nature of human AMPs and analyze their role in such autoimmune disorders like type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, Crohn’s disease and sarcoidosis. These peptides were shown to have a “double-sided” influence on the autoimmune disease pathogenesis. Thus, described facts should be taken into account for the development of new pharmaceutical agents to cure patients with autoimmune disorders. These agents could derive from natural antimicrobial peptides that in some cases modulate immune response. For example, it was shown that human AMPs are able to modulate complement system dysregulation of which is known to be one of the most dangerous pathogenic factors during autoimmune processes.
KW - antimicrobial peptides
KW - Autoimmune diseases
KW - cathelicidins
KW - α-defensins
KW - β-defensins
KW - RHEUMATOID-ARTHRITIS
KW - HUMAN CATHELICIDIN
KW - ALPHA-DEFENSINS
KW - POLYMORPHONUCLEAR LEUKOCYTE LYSOSOMES
KW - BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN
KW - PLASMACYTOID DENDRITIC CELLS
KW - HOST-DEFENSE PEPTIDE
KW - alpha-defensins
KW - HUMAN NEUTROPHIL PEPTIDES
KW - ARTICULAR-CARTILAGE
KW - HUMAN BETA-DEFENSIN-2
KW - beta-defensins
UR - http://www.scopus.com/inward/record.url?scp=85077864591&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/45f78750-de65-3c11-9122-b1b654b37017/
U2 - 10.1080/08916934.2020.1711517
DO - 10.1080/08916934.2020.1711517
M3 - Article
C2 - 31914804
AN - SCOPUS:85077864591
VL - 53
SP - 137
EP - 147
JO - Autoimmunity
JF - Autoimmunity
SN - 0891-6934
IS - 3
ER -
ID: 53114689