The number of yeast prions and prion-like proteins described since 1994 has grown from two to nearly twenty. If in the early years most scientists working with the classic mammalian prion, PrP Sc, were skeptical about the possibility of using the term prion to refer to yeast cytoplasmic elements with unusual properties, it is now clear that prion-like phenomena are widespread and that yeast can serve as a convenient model for studying them. Here we give a brief overview of the yeast prions discovered so far and focus our attention to the various approaches used to identify them. The prospects for the discovery of new yeast prions are also discussed.

Original languageEnglish
Article number11651
JournalInternational Journal of Molecular Sciences
Issue number14
StatePublished - 19 Jul 2023

    Research areas

  • Amyloid/metabolism, Animals, Mammals/metabolism, Prions/metabolism, Saccharomyces cerevisiae Proteins/metabolism, Saccharomyces cerevisiae/metabolism, proteome screenings, asparagine, evolution, glutamine, yeast, amyloid, protein aggregation, bioinformatics, prion

ID: 108517496