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Host-dependent serum specificity to the V3 domain of HIV-1. / Nabatov, A. A.; Masharsky, A. E.; Verevochkin, S. V.; Emelyanov, A. V.; Kozlov, A. P.

In: Scandinavian Journal of Immunology, Vol. 60, No. 5, 01.11.2004, p. 471-476.

Research output: Contribution to journal › Article › peer-review

Harvard

Nabatov, AA, Masharsky, AE, Verevochkin, SV, Emelyanov, AV & Kozlov, AP 2004, 'Host-dependent serum specificity to the V3 domain of HIV-1', Scandinavian Journal of Immunology, vol. 60, no. 5, pp. 471-476. https://doi.org/10.1111/j.0300-9475.2004.01506.x

APA

Nabatov, A. A., Masharsky, A. E., Verevochkin, S. V., Emelyanov, A. V., & Kozlov, A. P. (2004). Host-dependent serum specificity to the V3 domain of HIV-1. Scandinavian Journal of Immunology, 60(5), 471-476. https://doi.org/10.1111/j.0300-9475.2004.01506.x

Vancouver

Nabatov AA, Masharsky AE, Verevochkin SV, Emelyanov AV, Kozlov AP. Host-dependent serum specificity to the V3 domain of HIV-1. Scandinavian Journal of Immunology. 2004 Nov 1;60(5):471-476. https://doi.org/10.1111/j.0300-9475.2004.01506.x

Author

Nabatov, A. A. ; Masharsky, A. E. ; Verevochkin, S. V. ; Emelyanov, A. V. ; Kozlov, A. P. / Host-dependent serum specificity to the V3 domain of HIV-1. In: Scandinavian Journal of Immunology. 2004 ; Vol. 60, No. 5. pp. 471-476.

BibTeX

@article{1edccd9b934e46ebae3e4a982834d826,
title = "Host-dependent serum specificity to the V3 domain of HIV-1",
abstract = "The previous studies of anti-HIV-1 humoral immune response have found the stable individual structural bias in the antibody production that reflects the changes in the immune functional network caused by HIV-1. The correlation between antigen structure, in particular the V3 domain of HIV-1, and the serum specificity to the structure remains unclear. To clarify the role of host individual factors in the serum specificity, we used the slightly modified HIV-1 serotyping methodological approach for the sera of the patients infected with HIV-1 with a different level of genetic similarity. Substantial discrepancy between serum specificities and antigen structure was found. Patients infected with HIV-1 carrying similar and identical V3 sequences had significantly different serum specificities. The opposite situation was often observed as well. The results of the study suggest that the influence of the V3 loop structure in the development of humoral immune response to the V3 loop is substantially modified in a patient-specific manner.",
author = "Nabatov, {A. A.} and Masharsky, {A. E.} and Verevochkin, {S. V.} and Emelyanov, {A. V.} and Kozlov, {A. P.}",
year = "2004",
month = nov,
day = "1",
doi = "10.1111/j.0300-9475.2004.01506.x",
language = "English",
volume = "60",
pages = "471--476",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Host-dependent serum specificity to the V3 domain of HIV-1

AU - Nabatov, A. A.

AU - Masharsky, A. E.

AU - Verevochkin, S. V.

AU - Emelyanov, A. V.

AU - Kozlov, A. P.

PY - 2004/11/1

Y1 - 2004/11/1

N2 - The previous studies of anti-HIV-1 humoral immune response have found the stable individual structural bias in the antibody production that reflects the changes in the immune functional network caused by HIV-1. The correlation between antigen structure, in particular the V3 domain of HIV-1, and the serum specificity to the structure remains unclear. To clarify the role of host individual factors in the serum specificity, we used the slightly modified HIV-1 serotyping methodological approach for the sera of the patients infected with HIV-1 with a different level of genetic similarity. Substantial discrepancy between serum specificities and antigen structure was found. Patients infected with HIV-1 carrying similar and identical V3 sequences had significantly different serum specificities. The opposite situation was often observed as well. The results of the study suggest that the influence of the V3 loop structure in the development of humoral immune response to the V3 loop is substantially modified in a patient-specific manner.

AB - The previous studies of anti-HIV-1 humoral immune response have found the stable individual structural bias in the antibody production that reflects the changes in the immune functional network caused by HIV-1. The correlation between antigen structure, in particular the V3 domain of HIV-1, and the serum specificity to the structure remains unclear. To clarify the role of host individual factors in the serum specificity, we used the slightly modified HIV-1 serotyping methodological approach for the sera of the patients infected with HIV-1 with a different level of genetic similarity. Substantial discrepancy between serum specificities and antigen structure was found. Patients infected with HIV-1 carrying similar and identical V3 sequences had significantly different serum specificities. The opposite situation was often observed as well. The results of the study suggest that the influence of the V3 loop structure in the development of humoral immune response to the V3 loop is substantially modified in a patient-specific manner.

UR - http://www.scopus.com/inward/record.url?scp=8444227784&partnerID=8YFLogxK

U2 - 10.1111/j.0300-9475.2004.01506.x

DO - 10.1111/j.0300-9475.2004.01506.x

M3 - Article

C2 - 15541039

AN - SCOPUS:8444227784

VL - 60

SP - 471

EP - 476

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 5

ER -

ID: 37699391