Hormonal Sex Inversion and Some Aspects of Its Genetic Determination in Chicken

Standard

Hormonal Sex Inversion and Some Aspects of Its Genetic Determination in Chicken. / Trukhina, A. V.; Lukina, N. A.; Smirnov, A. F.

In: Russian Journal of Genetics, Vol. 54, No. 9, 01.09.2018, p. 1069-1077.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{ee8130a80f46492fbc44a0413b4e2a61,

title = "Hormonal Sex Inversion and Some Aspects of Its Genetic Determination in Chicken",

abstract = "Different mechanisms of genetic sex determination in birds are considered. Special emphasis is placed on the influence of external factors (reduction of estrogen synthesis, inactivation of DNA methylases) on expression of key sex determining genes. The possibility of sex inversion in domestic chicken by aromatase inhibition, genomic DNA demethylation, and the effect of estrogen analogs on estrogen receptors was demonstrated. The results of these effects were analyzed and their effect on the development of gonads in one-day embryos was demonstrated. A suggestion on earlier aromatase activity in chicken embryos, weak effect of DNA demethylation with 5-azacytidine, and different mechanisms of the effect of estrogens and their analogs (tamoxifen) on the gonad development in chicken was made.",

keywords = "aromatase, chicken, gonads, sex determination, sex inversion",

author = "Trukhina, {A. V.} and Lukina, {N. A.} and Smirnov, {A. F.}",

year = "2018",

month = sep,

day = "1",

doi = "10.1134/S1022795418090144",

language = "English",

volume = "54",

pages = "1069--1077",

journal = "Russian Journal of Genetics",

issn = "1022-7954",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "9",

}

RIS

TY - JOUR

T1 - Hormonal Sex Inversion and Some Aspects of Its Genetic Determination in Chicken

AU - Trukhina, A. V.

AU - Lukina, N. A.

AU - Smirnov, A. F.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Different mechanisms of genetic sex determination in birds are considered. Special emphasis is placed on the influence of external factors (reduction of estrogen synthesis, inactivation of DNA methylases) on expression of key sex determining genes. The possibility of sex inversion in domestic chicken by aromatase inhibition, genomic DNA demethylation, and the effect of estrogen analogs on estrogen receptors was demonstrated. The results of these effects were analyzed and their effect on the development of gonads in one-day embryos was demonstrated. A suggestion on earlier aromatase activity in chicken embryos, weak effect of DNA demethylation with 5-azacytidine, and different mechanisms of the effect of estrogens and their analogs (tamoxifen) on the gonad development in chicken was made.

AB - Different mechanisms of genetic sex determination in birds are considered. Special emphasis is placed on the influence of external factors (reduction of estrogen synthesis, inactivation of DNA methylases) on expression of key sex determining genes. The possibility of sex inversion in domestic chicken by aromatase inhibition, genomic DNA demethylation, and the effect of estrogen analogs on estrogen receptors was demonstrated. The results of these effects were analyzed and their effect on the development of gonads in one-day embryos was demonstrated. A suggestion on earlier aromatase activity in chicken embryos, weak effect of DNA demethylation with 5-azacytidine, and different mechanisms of the effect of estrogens and their analogs (tamoxifen) on the gonad development in chicken was made.

KW - aromatase

KW - chicken

KW - gonads

KW - sex determination

KW - sex inversion

UR - http://www.scopus.com/inward/record.url?scp=85053464808&partnerID=8YFLogxK

U2 - 10.1134/S1022795418090144

DO - 10.1134/S1022795418090144

M3 - Article

AN - SCOPUS:85053464808

VL - 54

SP - 1069

EP - 1077

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 9

ER -

ID: 36075701