TY - JOUR

T1 - HMG-B transcription factors of unicellular opisthokonts and their relatedness to the Sox-Tcf/Lef-Mata proteins of Metazoa and fungi

AU - Pozdnyakov, I.R.

AU - Selyuk, A.O.

AU - Kalashnikova, V.A.

AU - Karpov, S.A.

N1 - Export Date: 19 October 2024 CODEN: GENED Адрес для корреспонденции: Pozdnyakov, I.R.Universitetskaya nab., 1-3, Russian Federation; эл. почта: Igor.Pozdnyakov@zin.ru Химические вещества/CAS: human menopausal gonadotropin, 61489-71-2; high mobility group B protein, 431548-19-5; Fungal Proteins; HMGB Proteins; SOX Transcription Factors; Transcription Factors Сведения о финансировании: 122031100281-5, 122031100260-0 Сведения о финансировании: Russian Science Foundation, RSF, 21-74-20089 Сведения о финансировании: Russian Science Foundation, RSF Текст о финансировании 1: We thank V.V. Zlatogursky for discussing the materials, the team of Invertebrate Zoology Department of SPbSU for collaboration and the staff of the Zoological Institute of the Russian Academy of Sciences for creating comfortable working conditions. This work was made in the frame of lab topic 122031100281-5 (I.R. Pozdnyakov), 122031100260-0 (S.A. Karpov) ZIN RAS and supported by RSF grant 21-74-20089 (Protein coding genes analysis, manuscript writing). Текст о финансировании 2: This work was made in the frame of lab topic 122031100281-5 (I.R. Pozdnyakov), 122031100260-0 (S.A. Karpov) ZIN RAS and supported by RSF grant 21-74-20089 (Protein coding genes analysis, manuscript writing).

PY - 2024/8/30

Y1 - 2024/8/30

N2 - A phylogenetic analysis of transcription factors of the Sox-Tcf/Lef-Mata (STM) family of the HMG-B superfamily was carried out in order to clarify the evolutionary roots of the Wnt signaling pathway in unicellular organisms. The data set for analysis included protein sequences of metazoans, fungi, unicellular opisthokonts, apusomonads and amoebozoans. The topology of the phylogenetic tree suggests that STM-related proteins arose in the common ancestor of Opisthokonta and Amoebozoa, two of amoebozoan STM proteins are sister-related to opisthokont ones and the three known lineages of STM transcription factors (STM family in narrow sence) are found in Opisthokonta only. Of these, the holozoan Sox protein branch is the result of either the first or second branching, that originated in the common ancestor of Opisthokonta. The lineage containing Tcf/Lef proteins (holozoan) and the lineage containing Mata proteins (holomycotan) are sister. They derived either at the time of the Holozoa and Holomycota divergence or originate from two paralogs of the common ancestor of Opisthokonta, which arose after the separation of the Sox lineage. Interaction with Armadillo-like proteins may be an original feature of the STM protein family and existed in the unicellular ancestors of multicellular animals; a connection is possible between the presence of Mata-related proteins in Aphelidium protococcorum and specific genome feature of this species. © 2024 Elsevier B.V.

AB - A phylogenetic analysis of transcription factors of the Sox-Tcf/Lef-Mata (STM) family of the HMG-B superfamily was carried out in order to clarify the evolutionary roots of the Wnt signaling pathway in unicellular organisms. The data set for analysis included protein sequences of metazoans, fungi, unicellular opisthokonts, apusomonads and amoebozoans. The topology of the phylogenetic tree suggests that STM-related proteins arose in the common ancestor of Opisthokonta and Amoebozoa, two of amoebozoan STM proteins are sister-related to opisthokont ones and the three known lineages of STM transcription factors (STM family in narrow sence) are found in Opisthokonta only. Of these, the holozoan Sox protein branch is the result of either the first or second branching, that originated in the common ancestor of Opisthokonta. The lineage containing Tcf/Lef proteins (holozoan) and the lineage containing Mata proteins (holomycotan) are sister. They derived either at the time of the Holozoa and Holomycota divergence or originate from two paralogs of the common ancestor of Opisthokonta, which arose after the separation of the Sox lineage. Interaction with Armadillo-like proteins may be an original feature of the STM protein family and existed in the unicellular ancestors of multicellular animals; a connection is possible between the presence of Mata-related proteins in Aphelidium protococcorum and specific genome feature of this species. © 2024 Elsevier B.V.

KW - Aphelida

KW - Choanoflagellate

KW - HMG-B

KW - Holomycota

KW - Holozoa

KW - Sox transcription factors

KW - Tcf/Lef

KW - Unicellular opisthokonts

KW - Wnt signaling pathway

KW - human menopausal gonadotropin

KW - transcription factor

KW - transcription factor Sox

KW - fungal protein

KW - high mobility group B protein

KW - amino acid sequence

KW - Amoebozoa

KW - Arabidopsis thaliana

KW - armadillo

KW - Article

KW - bootstrapping

KW - choanoflagellate

KW - computer model

KW - fungus

KW - genetic similarity

KW - human

KW - male

KW - nonhuman

KW - Opisthokonta

KW - paralogy

KW - phylogenetic tree

KW - phylogeny

KW - protein family

KW - protein structure

KW - sequence alignment

KW - signal transduction

KW - taxonomy

KW - Wnt signaling

KW - Xenopus laevis

KW - animal

KW - genetics

KW - metabolism

KW - molecular evolution

KW - Animals

KW - Evolution, Molecular

KW - Fungal Proteins

KW - Fungi

KW - HMGB Proteins

KW - Phylogeny

KW - SOX Transcription Factors

KW - Transcription Factors

KW - Wnt Signaling Pathway

UR - https://www.mendeley.com/catalogue/9572dbe0-865f-3b9f-9408-54223bca07ba/

U2 - 10.1016/j.gene.2024.148520

DO - 10.1016/j.gene.2024.148520

M3 - статья

VL - 921

JO - Gene

JF - Gene

SN - 0378-1119

M1 - 148520

ER -