Heterogeneity of the barrier properties of the colon in rat

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Heterogeneity of the barrier properties of the colon in rat. / Bekusova, Viktoria; Fatyykhov, Ilyas; Amasheh, Salah; Markov, Alexander.

In: Biological Communications, Vol. 66, No. 2, 30.06.2021, p. 160-170.

Research output: Contribution to journal › Article › peer-review

Author

Bekusova, Viktoria ; Fatyykhov, Ilyas ; Amasheh, Salah ; Markov, Alexander. / Heterogeneity of the barrier properties of the colon in rat. In: Biological Communications. 2021 ; Vol. 66, No. 2. pp. 160-170.

BibTeX

@article{ef15e04e05b0488f883b5e6d8c86d7d6,

title = "Heterogeneity of the barrier properties of the colon in rat",

abstract = "The incidence of colorectal cancer in different parts of the large intestine is notthe same, as tumors more often appear in the distal part of the colon comparedto the proximal one. The purpose of this study was to investigate heterogeneity of the barrier properties of the colon and clarify the effects of Prostaglandin E2 and interleukin-1beta on its different parts. An in-depth analysis of short circuit current, transepithelial electrical resistance and paracellular permeability for sodium fluorescein in Ussing chambers showed that the proximal part of the colon was less permeable compared to the distal one and the substances had different effects on the parameters of permeability in different parts of the colon. We suppose that heterogeneity of the barrier properties of the colon and various effects of their regulation by local molecular agents may determine different incidence of pathologies in the colon.",

keywords = "крысы, толстая кишка, трансэпителиальное сопротивление, проницаемость, барьерные свойства, простагландин Е2, Barrier properties, Colon, Heterogeneity, Interleukin-1beta, Intestinal permeability, Prostaglandin E2, Rat, Short circuit current, Transepithelial electrical resistance, Ussing chamber",

author = "Viktoria Bekusova and Ilyas Fatyykhov and Salah Amasheh and Alexander Markov",

note = "Publisher Copyright: {\textcopyright} 2021 Bekusova et al.",

year = "2021",

month = jun,

day = "30",

doi = "10.21638/spbu03.2021.207",

language = "English",

volume = "66",

pages = "160--170",

journal = "Biological Communications",

issn = "2542-2154",

publisher = "Издательство Санкт-Петербургского университета",

number = "2",

}

RIS

TY - JOUR

T1 - Heterogeneity of the barrier properties of the colon in rat

AU - Bekusova, Viktoria

AU - Fatyykhov, Ilyas

AU - Amasheh, Salah

AU - Markov, Alexander

PY - 2021/6/30

Y1 - 2021/6/30

N2 - The incidence of colorectal cancer in different parts of the large intestine is notthe same, as tumors more often appear in the distal part of the colon comparedto the proximal one. The purpose of this study was to investigate heterogeneity of the barrier properties of the colon and clarify the effects of Prostaglandin E2 and interleukin-1beta on its different parts. An in-depth analysis of short circuit current, transepithelial electrical resistance and paracellular permeability for sodium fluorescein in Ussing chambers showed that the proximal part of the colon was less permeable compared to the distal one and the substances had different effects on the parameters of permeability in different parts of the colon. We suppose that heterogeneity of the barrier properties of the colon and various effects of their regulation by local molecular agents may determine different incidence of pathologies in the colon.

AB - The incidence of colorectal cancer in different parts of the large intestine is notthe same, as tumors more often appear in the distal part of the colon comparedto the proximal one. The purpose of this study was to investigate heterogeneity of the barrier properties of the colon and clarify the effects of Prostaglandin E2 and interleukin-1beta on its different parts. An in-depth analysis of short circuit current, transepithelial electrical resistance and paracellular permeability for sodium fluorescein in Ussing chambers showed that the proximal part of the colon was less permeable compared to the distal one and the substances had different effects on the parameters of permeability in different parts of the colon. We suppose that heterogeneity of the barrier properties of the colon and various effects of their regulation by local molecular agents may determine different incidence of pathologies in the colon.

KW - крысы

KW - толстая кишка

KW - трансэпителиальное сопротивление

KW - проницаемость

KW - барьерные свойства

KW - простагландин Е2

KW - Barrier properties

KW - Colon

KW - Heterogeneity

KW - Interleukin-1beta

KW - Intestinal permeability

KW - Prostaglandin E2

KW - Rat

KW - Short circuit current

KW - Transepithelial electrical resistance

KW - Ussing chamber

UR - http://www.scopus.com/inward/record.url?scp=85109317750&partnerID=8YFLogxK

U2 - 10.21638/spbu03.2021.207

DO - 10.21638/spbu03.2021.207

M3 - Article

AN - SCOPUS:85109317750

VL - 66

SP - 160

EP - 170

JO - Biological Communications

JF - Biological Communications

SN - 2542-2154

IS - 2

ER -

ID: 84630791