Heterochromatic tandem repeats in the extracellular DNA

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Heterochromatic tandem repeats in the extracellular DNA. / Podgornaya, Olga I.; Vasilyeva, Irina N.; Bespalov, Vladimir G.

In: Advances in Experimental Medicine and Biology, Vol. 924, 01.01.2016, p. 85-89.

Research output: Contribution to journal › Article › peer-review

Author

Podgornaya, Olga I. ; Vasilyeva, Irina N. ; Bespalov, Vladimir G. / Heterochromatic tandem repeats in the extracellular DNA. In: Advances in Experimental Medicine and Biology. 2016 ; Vol. 924. pp. 85-89.

BibTeX

@article{246605a776804f97946af76f88306c6d,

title = "Heterochromatic tandem repeats in the extracellular DNA",

abstract = "Only limited sequencing data of the normal extracellular DNA (ecDNA) are currently available. The uptake of the ecDNA by cultured cells and its integration into the host chromatin have been demonstrated. A number of membrane-bearing vesicles in plasma and serum have been shown to carry nucleic acids. The presence of Tandem Repeat (TR) in both apoptotic DNA of HUVEC culture medium and membrane-associated DNA is shown. The existence and successful application of CREST serum also show the presence of fragments of the centromeric heterochromatin together with their TR and specific proteins in blood. Apparently, pericentromeric and centromeric DNA (TR) should be part of ecDNA in all cases.",

keywords = "Apoptosis, Centromeric proteins, Extracellular DNA, Membrane-associated DNA, Tandem repeats",

author = "Podgornaya, {Olga I.} and Vasilyeva, {Irina N.} and Bespalov, {Vladimir G.}",

year = "2016",

month = jan,

day = "1",

doi = "10.1007/978-3-319-42044-8_16",

language = "English",

volume = "924",

pages = "85--89",

journal = "Advances in Experimental Medicine and Biology",

issn = "0065-2598",

publisher = "Springer Nature",

}

RIS

TY - JOUR

T1 - Heterochromatic tandem repeats in the extracellular DNA

AU - Podgornaya, Olga I.

AU - Vasilyeva, Irina N.

AU - Bespalov, Vladimir G.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Only limited sequencing data of the normal extracellular DNA (ecDNA) are currently available. The uptake of the ecDNA by cultured cells and its integration into the host chromatin have been demonstrated. A number of membrane-bearing vesicles in plasma and serum have been shown to carry nucleic acids. The presence of Tandem Repeat (TR) in both apoptotic DNA of HUVEC culture medium and membrane-associated DNA is shown. The existence and successful application of CREST serum also show the presence of fragments of the centromeric heterochromatin together with their TR and specific proteins in blood. Apparently, pericentromeric and centromeric DNA (TR) should be part of ecDNA in all cases.

AB - Only limited sequencing data of the normal extracellular DNA (ecDNA) are currently available. The uptake of the ecDNA by cultured cells and its integration into the host chromatin have been demonstrated. A number of membrane-bearing vesicles in plasma and serum have been shown to carry nucleic acids. The presence of Tandem Repeat (TR) in both apoptotic DNA of HUVEC culture medium and membrane-associated DNA is shown. The existence and successful application of CREST serum also show the presence of fragments of the centromeric heterochromatin together with their TR and specific proteins in blood. Apparently, pericentromeric and centromeric DNA (TR) should be part of ecDNA in all cases.

KW - Apoptosis

KW - Centromeric proteins

KW - Extracellular DNA

KW - Membrane-associated DNA

KW - Tandem repeats

UR - http://www.scopus.com/inward/record.url?scp=84996479796&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-42044-8_16

DO - 10.1007/978-3-319-42044-8_16

M3 - Article

C2 - 27753024

AN - SCOPUS:84996479796

VL - 924

SP - 85

EP - 89

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -

ID: 41023724