Hashimotos' thyroiditis : Epidemiology, pathogenesis, clinic and therapy. / Ragusa, Francesca; Fallahi, Poupak; Elia, Giusy; Gonnella, Debora; Paparo, Sabrina Rosaria; Giusti, Claudia; Churilov, Leonid P.; Ferrari, Silvia Martina; Antonelli, Alessandro.
In: Best Practice and Research in Clinical Endocrinology and Metabolism, Vol. 33, No. 6, 101367, 2019, p. 101367.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Hashimotos' thyroiditis
T2 - Epidemiology, pathogenesis, clinic and therapy
AU - Ragusa, Francesca
AU - Fallahi, Poupak
AU - Elia, Giusy
AU - Gonnella, Debora
AU - Paparo, Sabrina Rosaria
AU - Giusti, Claudia
AU - Churilov, Leonid P.
AU - Ferrari, Silvia Martina
AU - Antonelli, Alessandro
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Hashimoto's thyroiditis (HT), the most frequent autoimmune thyroid disorders (AITDs), is the leading cause of hypothyroidism in the iodine-sufficient areas of the world. About 20-30% of patients suffers from HT, whose cause is thought to be a combination of genetic susceptibility and environmental factors that causes the loss of immunological tolerance, with a consequent autoimmune attack to the thyroid tissue and appearance of the disease. The pathologic features of lymphocytic infiltration, especially of T cells, and follicular destruction are the histological hallmark of autoimmune thyroiditis (AIT), that lead to gradual atrophy and fibrosis. An important role in the immune-pathogenesis of AITDs is due to chemokines and cytokines. In about 20% of patients, AITDs are associated with other organ specific/systemic autoimmune disorders. Many studies have demonstrated the relationship between papillary thyroid cancer and AITD. The treatment of hypothyroidism, as result of AIT, consists in daily assumption of synthetic levothyroxine.
AB - Hashimoto's thyroiditis (HT), the most frequent autoimmune thyroid disorders (AITDs), is the leading cause of hypothyroidism in the iodine-sufficient areas of the world. About 20-30% of patients suffers from HT, whose cause is thought to be a combination of genetic susceptibility and environmental factors that causes the loss of immunological tolerance, with a consequent autoimmune attack to the thyroid tissue and appearance of the disease. The pathologic features of lymphocytic infiltration, especially of T cells, and follicular destruction are the histological hallmark of autoimmune thyroiditis (AIT), that lead to gradual atrophy and fibrosis. An important role in the immune-pathogenesis of AITDs is due to chemokines and cytokines. In about 20% of patients, AITDs are associated with other organ specific/systemic autoimmune disorders. Many studies have demonstrated the relationship between papillary thyroid cancer and AITD. The treatment of hypothyroidism, as result of AIT, consists in daily assumption of synthetic levothyroxine.
KW - Autoimmune diseases
KW - autoimmune thyroid disorders
KW - autoimmune thyroiditis
KW - Hashimoto's thyroiditis
KW - hypothyroidism
KW - levothyroxine
KW - autoimmune diseases
UR - http://www.scopus.com/inward/record.url?scp=85076239887&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/hashimotos-thyroiditis-epidemiology-pathogenesis-clinic-therapy
U2 - 10.1016/j.beem.2019.101367
DO - 10.1016/j.beem.2019.101367
M3 - Review article
C2 - 31812326
VL - 33
SP - 101367
JO - Best Practice and Research: Clinical Endocrinology and Metabolism
JF - Best Practice and Research: Clinical Endocrinology and Metabolism
SN - 1521-690X
IS - 6
M1 - 101367
ER -
ID: 49837228