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Graphene oxide conjugated with doxorubicin : Synthesis, bioactivity, and biosafety. / Abdelhalim, Abdelsattar O.E.; Ageev, Sergei V.; Petrov, Andrey V.; Meshcheriakov, Anatolii A.; Luttsev, Mikhail D.; Vasina, Lubov V.; Nashchekina, Iuliia A.; Murin, Igor V.; Molchanov, Oleg E.; Maistrenko, Dmitrii N.; Potanin, Artem A.; Semenov, Konstantin N.; Sharoyko, Vladimir V.

In: Journal of Molecular Liquids, Vol. 359, 119156, 01.08.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Abdelhalim, AOE, Ageev, SV, Petrov, AV, Meshcheriakov, AA, Luttsev, MD, Vasina, LV, Nashchekina, IA, Murin, IV, Molchanov, OE, Maistrenko, DN, Potanin, AA, Semenov, KN & Sharoyko, VV 2022, 'Graphene oxide conjugated with doxorubicin: Synthesis, bioactivity, and biosafety', Journal of Molecular Liquids, vol. 359, 119156. https://doi.org/10.1016/j.molliq.2022.119156

APA

Abdelhalim, A. O. E., Ageev, S. V., Petrov, A. V., Meshcheriakov, A. A., Luttsev, M. D., Vasina, L. V., Nashchekina, I. A., Murin, I. V., Molchanov, O. E., Maistrenko, D. N., Potanin, A. A., Semenov, K. N., & Sharoyko, V. V. (2022). Graphene oxide conjugated with doxorubicin: Synthesis, bioactivity, and biosafety. Journal of Molecular Liquids, 359, [119156]. https://doi.org/10.1016/j.molliq.2022.119156

Vancouver

Abdelhalim AOE, Ageev SV, Petrov AV, Meshcheriakov AA, Luttsev MD, Vasina LV et al. Graphene oxide conjugated with doxorubicin: Synthesis, bioactivity, and biosafety. Journal of Molecular Liquids. 2022 Aug 1;359. 119156. https://doi.org/10.1016/j.molliq.2022.119156

Author

Abdelhalim, Abdelsattar O.E. ; Ageev, Sergei V. ; Petrov, Andrey V. ; Meshcheriakov, Anatolii A. ; Luttsev, Mikhail D. ; Vasina, Lubov V. ; Nashchekina, Iuliia A. ; Murin, Igor V. ; Molchanov, Oleg E. ; Maistrenko, Dmitrii N. ; Potanin, Artem A. ; Semenov, Konstantin N. ; Sharoyko, Vladimir V. / Graphene oxide conjugated with doxorubicin : Synthesis, bioactivity, and biosafety. In: Journal of Molecular Liquids. 2022 ; Vol. 359.

BibTeX

@article{bbb69770df5d4934a6429d027288173c,
title = "Graphene oxide conjugated with doxorubicin: Synthesis, bioactivity, and biosafety",
abstract = "This work presents a method for covalent functionalization of GO with a cytostatic preparation DOX with a loading of 87 %. The resulting nanomaterial was characterized using modern physicochemical methods (13C NMR, Raman, IR, UV/Vis spectroscopy, XPS, XRD, HRTEM). The synthesized conjugate showed significant antiaggregating activity and selective cytotoxicity towards the A549 cell line, significantly superior to individual DOX, as well as low cytotoxicity towards the non-cancer cell line HEK293. The complex biocompatibility study was conducted for the synthesized conjugate including hemocompatibility study, antioxidant activity, interaction with HSA and DNA, geno- and cytotoxicity investigation. At the same time, molecular dynamics investigation was performed in order to determine the features of intermolecular interaction between GO and DOX molecules.",
keywords = "Bioactivity, Doxorubicin, DPPH, Graphene oxide, HAS, Toxicity",
author = "Abdelhalim, {Abdelsattar O.E.} and Ageev, {Sergei V.} and Petrov, {Andrey V.} and Meshcheriakov, {Anatolii A.} and Luttsev, {Mikhail D.} and Vasina, {Lubov V.} and Nashchekina, {Iuliia A.} and Murin, {Igor V.} and Molchanov, {Oleg E.} and Maistrenko, {Dmitrii N.} and Potanin, {Artem A.} and Semenov, {Konstantin N.} and Sharoyko, {Vladimir V.}",
note = "Publisher Copyright: {\textcopyright} 2022",
year = "2022",
month = aug,
day = "1",
doi = "10.1016/j.molliq.2022.119156",
language = "English",
volume = "359",
journal = "Journal of Molecular Liquids",
issn = "0167-7322",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Graphene oxide conjugated with doxorubicin

T2 - Synthesis, bioactivity, and biosafety

AU - Abdelhalim, Abdelsattar O.E.

AU - Ageev, Sergei V.

AU - Petrov, Andrey V.

AU - Meshcheriakov, Anatolii A.

AU - Luttsev, Mikhail D.

AU - Vasina, Lubov V.

AU - Nashchekina, Iuliia A.

AU - Murin, Igor V.

AU - Molchanov, Oleg E.

AU - Maistrenko, Dmitrii N.

AU - Potanin, Artem A.

AU - Semenov, Konstantin N.

AU - Sharoyko, Vladimir V.

N1 - Publisher Copyright: © 2022

PY - 2022/8/1

Y1 - 2022/8/1

N2 - This work presents a method for covalent functionalization of GO with a cytostatic preparation DOX with a loading of 87 %. The resulting nanomaterial was characterized using modern physicochemical methods (13C NMR, Raman, IR, UV/Vis spectroscopy, XPS, XRD, HRTEM). The synthesized conjugate showed significant antiaggregating activity and selective cytotoxicity towards the A549 cell line, significantly superior to individual DOX, as well as low cytotoxicity towards the non-cancer cell line HEK293. The complex biocompatibility study was conducted for the synthesized conjugate including hemocompatibility study, antioxidant activity, interaction with HSA and DNA, geno- and cytotoxicity investigation. At the same time, molecular dynamics investigation was performed in order to determine the features of intermolecular interaction between GO and DOX molecules.

AB - This work presents a method for covalent functionalization of GO with a cytostatic preparation DOX with a loading of 87 %. The resulting nanomaterial was characterized using modern physicochemical methods (13C NMR, Raman, IR, UV/Vis spectroscopy, XPS, XRD, HRTEM). The synthesized conjugate showed significant antiaggregating activity and selective cytotoxicity towards the A549 cell line, significantly superior to individual DOX, as well as low cytotoxicity towards the non-cancer cell line HEK293. The complex biocompatibility study was conducted for the synthesized conjugate including hemocompatibility study, antioxidant activity, interaction with HSA and DNA, geno- and cytotoxicity investigation. At the same time, molecular dynamics investigation was performed in order to determine the features of intermolecular interaction between GO and DOX molecules.

KW - Bioactivity

KW - Doxorubicin

KW - DPPH

KW - Graphene oxide

KW - HAS

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=85129743523&partnerID=8YFLogxK

U2 - 10.1016/j.molliq.2022.119156

DO - 10.1016/j.molliq.2022.119156

M3 - Article

AN - SCOPUS:85129743523

VL - 359

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

SN - 0167-7322

M1 - 119156

ER -

ID: 96220132