The paper describes the alternative schemes for ensuring biological safety in the organization of the microbiological laboratories network on the territory of a megalopolis. For St. Petersburg, Russia, two options of work with biomaterial were considered—centralized and decentralized schemes. It is shown that continuous information support at all the stages of biomaterials life cycle is required to meet the quantitative and qualitative objectives. Such support is the most promising through an integrated approach based on the common data environment with the information modelling in GIS and the collaboration and tracking services.