Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

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Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system. / Щербинина, Вероника Дмитриевна; Vaido, A.I.; Khlebaeva, D. A.А.; Dyuzhikova, N. A.; Даев, Евгений Владиславович.

In: Biological Communications, Vol. 67, No. 1, 04.05.2022, p. 12-18.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{8ac019a04f3a40eaa45d50afd151715d,

title = "Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system",

abstract = "Changes of genome stability in hippocampal cells of male rats with hereditary high and low thresholds of nervus tibialis response to electric stimuli (HT and LT strains, respectively) were studied in unstressed and stressed animals. HT and LT originated from Wistar strain, males of which were also used as a control. The comet assay was used after prolonged emotional painful stressor action. There were no interstrain differences in the spontaneous percentage of DNA in comet tails (tDNA). However, the prolonged emotional pain stressor induced genome instability differently in animals of different strains. The highest level of DNA damage in hippocampal cells was shown in highly sensitive animals of LT strain. Males of Wistar strain had intermediate levels of tDNA, while HT animals had the lowest stress reactivity.",

keywords = "DNA damage, comet assay, stress, hippocampus, nervous sensitivity, selection, rats, genome instability, comet assay, DNA damage, genome instability, hippocampus, nervous sensitivity, rats, selection, stress",

author = "Щербинина, {Вероника Дмитриевна} and A.I. Vaido and Khlebaeva, {D. A.А.} and Dyuzhikova, {N. A.} and Даев, {Евгений Владиславович}",

note = "Publisher Copyright: {\textcopyright} 2022 Shcherbinina et al.",

year = "2022",

month = may,

day = "4",

doi = "10.21638/spbu03.2022.102",

language = "English",

volume = "67",

pages = "12--18",

journal = "Biological Communications",

issn = "2542-2154",

publisher = "Издательство Санкт-Петербургского университета",

number = "1",

}

RIS

TY - JOUR

T1 - Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

AU - Щербинина, Вероника Дмитриевна

AU - Vaido, A.I.

AU - Khlebaeva, D. A.А.

AU - Dyuzhikova, N. A.

AU - Даев, Евгений Владиславович

PY - 2022/5/4

Y1 - 2022/5/4

N2 - Changes of genome stability in hippocampal cells of male rats with hereditary high and low thresholds of nervus tibialis response to electric stimuli (HT and LT strains, respectively) were studied in unstressed and stressed animals. HT and LT originated from Wistar strain, males of which were also used as a control. The comet assay was used after prolonged emotional painful stressor action. There were no interstrain differences in the spontaneous percentage of DNA in comet tails (tDNA). However, the prolonged emotional pain stressor induced genome instability differently in animals of different strains. The highest level of DNA damage in hippocampal cells was shown in highly sensitive animals of LT strain. Males of Wistar strain had intermediate levels of tDNA, while HT animals had the lowest stress reactivity.

AB - Changes of genome stability in hippocampal cells of male rats with hereditary high and low thresholds of nervus tibialis response to electric stimuli (HT and LT strains, respectively) were studied in unstressed and stressed animals. HT and LT originated from Wistar strain, males of which were also used as a control. The comet assay was used after prolonged emotional painful stressor action. There were no interstrain differences in the spontaneous percentage of DNA in comet tails (tDNA). However, the prolonged emotional pain stressor induced genome instability differently in animals of different strains. The highest level of DNA damage in hippocampal cells was shown in highly sensitive animals of LT strain. Males of Wistar strain had intermediate levels of tDNA, while HT animals had the lowest stress reactivity.

KW - DNA damage, comet assay, stress, hippocampus, nervous sensitivity, selection, rats, genome instability

KW - comet assay

KW - DNA damage

KW - genome instability

KW - hippocampus

KW - nervous sensitivity

KW - rats

KW - selection

KW - stress

UR - https://www.mendeley.com/catalogue/6bdd2bb3-d0df-3c09-8ea5-5c3fe85eb58f/

UR - http://www.scopus.com/inward/record.url?scp=85140593211&partnerID=8YFLogxK

U2 - 10.21638/spbu03.2022.102

DO - 10.21638/spbu03.2022.102

M3 - Article

VL - 67

SP - 12

EP - 18

JO - Biological Communications

JF - Biological Communications

SN - 2542-2154

IS - 1

ER -

ID: 96818884