Research output: Contribution to journal › Article › peer-review
Genetic determinants of the efficiency of climatotherapy in patients with chronic heart failure. / Kovlen, Denis V.; Tishakov, A. Yu; Glotov, O. S.; Moskalenko, M. V.; Demin, G. S.; Bitsadze, A. N.; Chernyshev, A. V.; Bratova, N. I.; Ivashchenko, T. E.; Obrezan, A. G.; Ponomarenko, G. N.
In: Bulletin of Experimental Biology and Medicine, Vol. 143, No. 1, 01.2007, p. 26-31.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Genetic determinants of the efficiency of climatotherapy in patients with chronic heart failure
AU - Kovlen, Denis V.
AU - Tishakov, A. Yu
AU - Glotov, O. S.
AU - Moskalenko, M. V.
AU - Demin, G. S.
AU - Bitsadze, A. N.
AU - Chernyshev, A. V.
AU - Bratova, N. I.
AU - Ivashchenko, T. E.
AU - Obrezan, A. G.
AU - Ponomarenko, G. N.
PY - 2007/1
Y1 - 2007/1
N2 - We studied the dependence of climatotherapy effectiveness in patients with chronic heart failure (functional classes 0-II) on Ca2+-ATPase, phospholamban, β1-adrenoceptor, and insulin-like growth factor 1 gene polymorphisms and possible interaction of these genes during the realization of the effect of climatotherapy. The effectiveness of climatotherapy depended on polymorphism of the studied genes; the maximum effect was attained in patients with the GG polymorphism of the Ca2+-ATPase gene, GT polymorphism of the phospholamban gene, ArgGly polymorphism of the β1-adrenoceptor gene, and 19/19 polymorphism of the insulin-like growth factor 1 gene. We demonstrated additive interaction of Ca2+-ATPase and β1-adrenoceptor genes during the realization of the cardiotonic effect of climatotherapy.
AB - We studied the dependence of climatotherapy effectiveness in patients with chronic heart failure (functional classes 0-II) on Ca2+-ATPase, phospholamban, β1-adrenoceptor, and insulin-like growth factor 1 gene polymorphisms and possible interaction of these genes during the realization of the effect of climatotherapy. The effectiveness of climatotherapy depended on polymorphism of the studied genes; the maximum effect was attained in patients with the GG polymorphism of the Ca2+-ATPase gene, GT polymorphism of the phospholamban gene, ArgGly polymorphism of the β1-adrenoceptor gene, and 19/19 polymorphism of the insulin-like growth factor 1 gene. We demonstrated additive interaction of Ca2+-ATPase and β1-adrenoceptor genes during the realization of the cardiotonic effect of climatotherapy.
KW - Chronic heart failure
KW - Climatotherapy
KW - Genetic polymorphism
UR - http://www.scopus.com/inward/record.url?scp=34249022751&partnerID=8YFLogxK
U2 - 10.1007/s10517-007-0008-z
DO - 10.1007/s10517-007-0008-z
M3 - Article
C2 - 18019005
AN - SCOPUS:34249022751
VL - 143
SP - 26
EP - 31
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 1
ER -
ID: 89272894