G protein-coupled receptor kinases as regulators of dopamine receptor functions. / Gurevich, EV; Gainetdinov, RR; Gurevich, VV.
In: Pharmacological Research, 2016.Research output: Contribution to journal › Literature review
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TY - JOUR
T1 - G protein-coupled receptor kinases as regulators of dopamine receptor functions.
AU - Gurevich, EV
AU - Gainetdinov, RR
AU - Gurevich, VV.
PY - 2016
Y1 - 2016
N2 - Actions of the neurotransmitter dopamine in the brain are mediated by dopamine receptors that belong to the superfamily of G protein-coupled receptors (GPCRs). Mammals have five dopamine receptor subtypes, D1 through D5. D1 and D5 couple to Gs/olf and activate adenylyl cyclase, whereas D2, D3, and D4 couple to Gi/o and inhibit it. Most GPCRs upon activation by an agonist are phosphorylated by GPCR kinases (GRKs). The GRK phosphorylation makes receptors high-affinity binding partners for arrestin proteins. Arrestin binding to active phosphorylated receptors stops further G protein activation and promotes receptor internalization, recycling or degradation, thereby regulating their signaling and trafficking. Four non- visual GRKs are expressed in striatal neurons. Here we describe known effects of individual GRKs on dopamine receptors in cell culture and in the two in vivo models of dopamine-mediated signaling: behavioral response to psychostimulants and L-DOPA- induced dyskinesia. Dyskinesia, associated with do
AB - Actions of the neurotransmitter dopamine in the brain are mediated by dopamine receptors that belong to the superfamily of G protein-coupled receptors (GPCRs). Mammals have five dopamine receptor subtypes, D1 through D5. D1 and D5 couple to Gs/olf and activate adenylyl cyclase, whereas D2, D3, and D4 couple to Gi/o and inhibit it. Most GPCRs upon activation by an agonist are phosphorylated by GPCR kinases (GRKs). The GRK phosphorylation makes receptors high-affinity binding partners for arrestin proteins. Arrestin binding to active phosphorylated receptors stops further G protein activation and promotes receptor internalization, recycling or degradation, thereby regulating their signaling and trafficking. Four non- visual GRKs are expressed in striatal neurons. Here we describe known effects of individual GRKs on dopamine receptors in cell culture and in the two in vivo models of dopamine-mediated signaling: behavioral response to psychostimulants and L-DOPA- induced dyskinesia. Dyskinesia, associated with do
KW - Dopamine receptor
KW - Dyskinesia
KW - G protein-coupled receptor kinase
KW - L-DOPA
KW - Parkinson’s disease
KW - Psychostimulants
M3 - Обзор литературы
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
ER -
ID: 7599166