Research output: Contribution to journal › Article › peer-review
Functionalization of terpene alcohols with 1-sulfonyl-1,2,3-triazoles: synthesis of N-(2-terpenyloxyethenyl/ethyl)sulfonamides. / Васильченко, Дмитрий Сергеевич; Шафеева, Мария; Рогачева, Елизавета Владимировна; Краева, Людмила Александровна; Бунев, Александр; Третьякова, Татьяна; Чистый, Леонид Сергеевич; Ростовский, Николай Витальевич; Тришин, Юрий.
In: Mendeleev Communications, Vol. 35, No. 5, 17.07.2025, p. 518–520.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Functionalization of terpene alcohols with 1-sulfonyl-1,2,3-triazoles: synthesis of N-(2-terpenyloxyethenyl/ethyl)sulfonamides
AU - Васильченко, Дмитрий Сергеевич
AU - Шафеева, Мария
AU - Рогачева, Елизавета Владимировна
AU - Краева, Людмила Александровна
AU - Бунев, Александр
AU - Третьякова, Татьяна
AU - Чистый, Леонид Сергеевич
AU - Ростовский, Николай Витальевич
AU - Тришин, Юрий
PY - 2025/7/17
Y1 - 2025/7/17
N2 - New N-(2-aryl-2-terpenyloxyethenyl)sulfonamides bearing two pharmacophoric terpenyloxy and sulfonamide groups linked through an ethylene bridge were synthesized by the reaction of p-menthol, allobetulin or isoborneol with 4-aryl-1-arylsulfonyl-1,2,3-triazoles in the presence of rhodium(ii) pivalate. A significant part of the compounds obtained possessed low stability, which necessitated their hydrogenation into more stable N-(2-aryl-2-terpenyloxyethyl)-sulfonamides. Some of the synthesized compounds exhibited high antibacterial and moderate cytotoxic activity.
AB - New N-(2-aryl-2-terpenyloxyethenyl)sulfonamides bearing two pharmacophoric terpenyloxy and sulfonamide groups linked through an ethylene bridge were synthesized by the reaction of p-menthol, allobetulin or isoborneol with 4-aryl-1-arylsulfonyl-1,2,3-triazoles in the presence of rhodium(ii) pivalate. A significant part of the compounds obtained possessed low stability, which necessitated their hydrogenation into more stable N-(2-aryl-2-terpenyloxyethyl)-sulfonamides. Some of the synthesized compounds exhibited high antibacterial and moderate cytotoxic activity.
U2 - 10.71267/mencom.7712
DO - 10.71267/mencom.7712
M3 - Article
VL - 35
SP - 518
EP - 520
JO - Mendeleev Communications
JF - Mendeleev Communications
SN - 0959-9436
IS - 5
ER -
ID: 142122574