Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2

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Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2. / Zhang, X.; Beaulieu, J. M.; Gainetdinov, R. R.; Caron, M. G.

In: Cellular and Molecular Life Sciences, Vol. 63, No. 1, 01.01.2006, p. 6-11.

Research output: Contribution to journal › Review article › peer-review

Author

Zhang, X. ; Beaulieu, J. M. ; Gainetdinov, R. R. ; Caron, M. G. / Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2. In: Cellular and Molecular Life Sciences. 2006 ; Vol. 63, No. 1. pp. 6-11.

BibTeX

@article{6ea6fe817cc1482a9b3f588fce5b9d77,

title = "Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2",

abstract = "Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2.",

keywords = "Brain serotonin, Congenic mice, PC12 cells, Single nucleotide polymorphism (SNP), Tryptophan hydroxylase-2 (TPH2)",

author = "X. Zhang and Beaulieu, {J. M.} and Gainetdinov, {R. R.} and Caron, {M. G.}",

year = "2006",

month = jan,

day = "1",

doi = "10.1007/s00018-005-5417-4",

language = "English",

volume = "63",

pages = "6--11",

journal = "Cellular and Molecular Life Sciences",

issn = "1420-682X",

publisher = "Birkh{\"a}user Verlag AG",

number = "1",

}

RIS

TY - JOUR

T1 - Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2

AU - Zhang, X.

AU - Beaulieu, J. M.

AU - Gainetdinov, R. R.

AU - Caron, M. G.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2.

AB - Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2.

KW - Brain serotonin

KW - Congenic mice

KW - PC12 cells

KW - Single nucleotide polymorphism (SNP)

KW - Tryptophan hydroxylase-2 (TPH2)

UR - http://www.scopus.com/inward/record.url?scp=30744436805&partnerID=8YFLogxK

U2 - 10.1007/s00018-005-5417-4

DO - 10.1007/s00018-005-5417-4

M3 - Review article

C2 - 16378243

AN - SCOPUS:30744436805

VL - 63

SP - 6

EP - 11

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 1

ER -

ID: 36473130