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From BDNF to reading: Neural activation and phonological processing as multiple mediators. / Mascheretti, Sara; Perdue, Meaghan V. ; Feng, Bei; Andreola, Chiara; Dionne, Ginette; Jasińska, Kaja K.; Pugh, Kenneth R.; Grigorenko, Elena L.; Landi, Nicole .

In: Behavioural Brain Research, Vol. 396, 112859, 01.01.2021.

Research output: Contribution to journal › Article › peer-review

Harvard

Mascheretti, S, Perdue, MV, Feng, B, Andreola, C, Dionne, G, Jasińska, KK, Pugh, KR, Grigorenko, EL & Landi, N 2021, 'From BDNF to reading: Neural activation and phonological processing as multiple mediators', Behavioural Brain Research, vol. 396, 112859. https://doi.org/10.1016/j.bbr.2020.112859

APA

Mascheretti, S., Perdue, M. V., Feng, B., Andreola, C., Dionne, G., Jasińska, K. K., Pugh, K. R., Grigorenko, E. L., & Landi, N. (2021). From BDNF to reading: Neural activation and phonological processing as multiple mediators. Behavioural Brain Research, 396, [112859]. https://doi.org/10.1016/j.bbr.2020.112859

Vancouver

Mascheretti S, Perdue MV, Feng B, Andreola C, Dionne G, Jasińska KK et al. From BDNF to reading: Neural activation and phonological processing as multiple mediators. Behavioural Brain Research. 2021 Jan 1;396. 112859. https://doi.org/10.1016/j.bbr.2020.112859

Author

Mascheretti, Sara ; Perdue, Meaghan V. ; Feng, Bei ; Andreola, Chiara ; Dionne, Ginette ; Jasińska, Kaja K. ; Pugh, Kenneth R. ; Grigorenko, Elena L. ; Landi, Nicole . / From BDNF to reading: Neural activation and phonological processing as multiple mediators. In: Behavioural Brain Research. 2021 ; Vol. 396.

BibTeX

@article{31e1519c08a64c3fae8eff1acea36efc,
title = "From BDNF to reading: Neural activation and phonological processing as multiple mediators",
abstract = "The BDNF gene is a prominent promoter of neuronal development, maturation and plasticity. Its Val66Met polymorphism affects brain morphology and function within several areas and is associated with several cognitive functions and neurodevelopmental disorder susceptibility. Recently, it has been associated with reading, reading-related traits and altered neural activation in reading–related brain regions. However, it remains unknown if the intermediate phenotypes (IPs, such as brain activation and phonological skills) mediate the pathway from gene to reading or reading disability. By conducting a serial multiple mediation model in a sample of 94 children (age 5–13), our findings revealed no direct effects of genotype on reading. Instead, we found that genotype is associated with brain activation in reading-related and more domain general regions which in turn is associated with phonological processing which is associated with reading. These findings suggest that the BDNF-Val66Met polymorphism is related to reading via phonological processing and functional activation. These results support brain imaging data and neurocognitive traits as viable IPs for complex behaviors.",
keywords = "BDNF-Val Met polymorphism, Compensatory mechanisms, Intermediate phenotypes, Reading, Serial multiple mediation model, Humans, Child, Preschool, Brain-Derived Neurotrophic Factor/genetics, Genotype, Magnetic Resonance Imaging, Phenotype, Cerebral Cortex/diagnostic imaging, Adolescent, Psycholinguistics, Polymorphism, Single Nucleotide, Child, PRINT, HUMAN-MEMORY, BDNF-Val(66)Met polymorphism, GENERALIST GENES, ENDOPHENOTYPE CONCEPT, DEVELOPMENTAL DYSLEXIA, LANGUAGE, BRAIN-DEVELOPMENT, VAL66MET POLYMORPHISM, CHILDREN, SAMPLE-SIZE, BDNF-Val66Met polymorphism",
author = "Sara Mascheretti and Perdue, {Meaghan V.} and Bei Feng and Chiara Andreola and Ginette Dionne and Jasi{\'n}ska, {Kaja K.} and Pugh, {Kenneth R.} and Grigorenko, {Elena L.} and Nicole Landi",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2021",
month = jan,
day = "1",
doi = "10.1016/j.bbr.2020.112859",
language = "English",
volume = "396",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - From BDNF to reading: Neural activation and phonological processing as multiple mediators

AU - Mascheretti, Sara

AU - Perdue, Meaghan V.

AU - Feng, Bei

AU - Andreola, Chiara

AU - Dionne, Ginette

AU - Jasińska, Kaja K.

AU - Pugh, Kenneth R.

AU - Grigorenko, Elena L.

AU - Landi, Nicole

N1 - Publisher Copyright: © 2020 Elsevier B.V.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - The BDNF gene is a prominent promoter of neuronal development, maturation and plasticity. Its Val66Met polymorphism affects brain morphology and function within several areas and is associated with several cognitive functions and neurodevelopmental disorder susceptibility. Recently, it has been associated with reading, reading-related traits and altered neural activation in reading–related brain regions. However, it remains unknown if the intermediate phenotypes (IPs, such as brain activation and phonological skills) mediate the pathway from gene to reading or reading disability. By conducting a serial multiple mediation model in a sample of 94 children (age 5–13), our findings revealed no direct effects of genotype on reading. Instead, we found that genotype is associated with brain activation in reading-related and more domain general regions which in turn is associated with phonological processing which is associated with reading. These findings suggest that the BDNF-Val66Met polymorphism is related to reading via phonological processing and functional activation. These results support brain imaging data and neurocognitive traits as viable IPs for complex behaviors.

AB - The BDNF gene is a prominent promoter of neuronal development, maturation and plasticity. Its Val66Met polymorphism affects brain morphology and function within several areas and is associated with several cognitive functions and neurodevelopmental disorder susceptibility. Recently, it has been associated with reading, reading-related traits and altered neural activation in reading–related brain regions. However, it remains unknown if the intermediate phenotypes (IPs, such as brain activation and phonological skills) mediate the pathway from gene to reading or reading disability. By conducting a serial multiple mediation model in a sample of 94 children (age 5–13), our findings revealed no direct effects of genotype on reading. Instead, we found that genotype is associated with brain activation in reading-related and more domain general regions which in turn is associated with phonological processing which is associated with reading. These findings suggest that the BDNF-Val66Met polymorphism is related to reading via phonological processing and functional activation. These results support brain imaging data and neurocognitive traits as viable IPs for complex behaviors.

KW - BDNF-Val Met polymorphism

KW - Compensatory mechanisms

KW - Intermediate phenotypes

KW - Reading

KW - Serial multiple mediation model

KW - Humans

KW - Child, Preschool

KW - Brain-Derived Neurotrophic Factor/genetics

KW - Genotype

KW - Magnetic Resonance Imaging

KW - Phenotype

KW - Cerebral Cortex/diagnostic imaging

KW - Adolescent

KW - Psycholinguistics

KW - Polymorphism, Single Nucleotide

KW - Child

KW - PRINT

KW - HUMAN-MEMORY

KW - BDNF-Val(66)Met polymorphism

KW - GENERALIST GENES

KW - ENDOPHENOTYPE CONCEPT

KW - DEVELOPMENTAL DYSLEXIA

KW - LANGUAGE

KW - BRAIN-DEVELOPMENT

KW - VAL66MET POLYMORPHISM

KW - CHILDREN

KW - SAMPLE-SIZE

KW - BDNF-Val66Met polymorphism

UR - https://www.sciencedirect.com/science/article/pii/S0166432820305581

UR - http://www.scopus.com/inward/record.url?scp=85090148841&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/1f20b86f-1ec6-3fc0-970f-03ae803fea72/

U2 - 10.1016/j.bbr.2020.112859

DO - 10.1016/j.bbr.2020.112859

M3 - Article

C2 - 32810467

VL - 396

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

M1 - 112859

ER -

ID: 69823564