TY - JOUR

T1 - Formation of a Hollow Core in Dendrimers in Solvents

AU - Маркелов, Денис Анатольевич

AU - Семисалова, Анна Сергеевна

AU - Мазо, Михаил Абрамович

N1 - Publisher Copyright: © 2021 The Authors. Macromolecular Chemistry and Physics published by Wiley-VCH GmbH

PY - 2021/8

Y1 - 2021/8

N2 - Dendrimers are perfect tree-like radially symmetric macromolecules with regular branching. Due to their architecture, dendrimers possess a set of unique properties, including high penetrating ability and a large number of functionalizable terminal groups. Practical use of dendrimers as delivery agents or nanoreactors in many cases involves a free space in a dendrimer interior. The question about presence of a hollow core (a cavity) inside the dendrimer molecule placed in a solvent attracts interest of researchers since the discovery of dendrimers. This review presents a rigorous discussion on the dendrimer structure in solution. The main objective is to draw attention to the difference in the structure of homopolymer and copolymer dendrimers. Theoretical studies typically consider homopolymer dendrimers (with similar inner and terminal segments), whereas experiments often examine dendrimers with massive terminal groups which chemical structure is different from the structure of the dendrimer inner groups. In the latter case, dendrimer is a copolymer macromolecule, and its conformation can depend on additional factors, such as solvent selectivity, or poor compatibility of terminal and core groups. The influence of these factors can lead to the formation of a region with a lower polymer density inside the dendrimer.

AB - Dendrimers are perfect tree-like radially symmetric macromolecules with regular branching. Due to their architecture, dendrimers possess a set of unique properties, including high penetrating ability and a large number of functionalizable terminal groups. Practical use of dendrimers as delivery agents or nanoreactors in many cases involves a free space in a dendrimer interior. The question about presence of a hollow core (a cavity) inside the dendrimer molecule placed in a solvent attracts interest of researchers since the discovery of dendrimers. This review presents a rigorous discussion on the dendrimer structure in solution. The main objective is to draw attention to the difference in the structure of homopolymer and copolymer dendrimers. Theoretical studies typically consider homopolymer dendrimers (with similar inner and terminal segments), whereas experiments often examine dendrimers with massive terminal groups which chemical structure is different from the structure of the dendrimer inner groups. In the latter case, dendrimer is a copolymer macromolecule, and its conformation can depend on additional factors, such as solvent selectivity, or poor compatibility of terminal and core groups. The influence of these factors can lead to the formation of a region with a lower polymer density inside the dendrimer.

KW - NMR

KW - carbosilane dendrimers

KW - copolymer dendrimers

KW - dendrimers

KW - hollow cores

KW - FLEXIBLE SPACER-CHAINS

KW - MOLECULAR-DYNAMICS SIMULATION

KW - MONTE-CARLO

KW - CARBOSILANE DENDRIMER

KW - NMR RELAXATION

KW - POLY(AMIDOAMINE) PAMAM DENDRIMERS

KW - CHARGED DENDRIMERS

KW - LYSINE DENDRIMERS

KW - POLYPHENYLENE DENDRIMERS

KW - ANGLE NEUTRON-SCATTERING

UR - http://www.scopus.com/inward/record.url?scp=85109137483&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/773bfd55-eddc-39d9-911d-6fd6c56e72d1/

U2 - 10.1002/macp.202100085

DO - 10.1002/macp.202100085

M3 - Review article

VL - 222

JO - Macromolecular Chemistry and Physics

JF - Macromolecular Chemistry and Physics

SN - 1022-1352

IS - 15

M1 - 2100085

ER -