Despite increasing recognition of the importance of entrepreneurial orientation (EO), insufficient attention has been devoted to international factors which foster EO. In this paper, we examine managerial international exposure and regional involvement in international economic activity as two potential key drivers of firms’ EO formation. We explore these focal relationships using a robust sample of 769 manufacturing firms from Russia, a BRIC country and emerging economy that has received relatively scant attention within the literature. Our findings indicate that managerial international exposure increases firm’s EO, and that this effect is weakened as regional involvement in international activity increases.