Research output: Contribution to journal › Article › peer-review
Fixation of DNA directly on optical waveguide surfaces for molecular probe biosensor development. / Karymov, M. A.; Kruchinin, A. A.; Tarantov, Yu A.; Balova, I. A.; Remisova, L. A.; Vlasov, Yu G.
In: Sensors and Actuators: B. Chemical, Vol. 29, No. 1-3, 10.1995, p. 324-327.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Fixation of DNA directly on optical waveguide surfaces for molecular probe biosensor development
AU - Karymov, M. A.
AU - Kruchinin, A. A.
AU - Tarantov, Yu A.
AU - Balova, I. A.
AU - Remisova, L. A.
AU - Vlasov, Yu G.
N1 - Funding Information: This work was supportedi,n part, by a Soros Hu-manitarianF oundationsG rant awardedb y the American Physical Society.
PY - 1995/10
Y1 - 1995/10
N2 - Covalent attachment of DNA molecules to the surface of silicon nitride without an intermediate polymer layer is described. It is shown that the silicon nitride has a sorption capacity no less than 200 pg/mm2, hybridization efficiency being close to 100%. The expected value of refractive index changes in the molecular layer under hybridization is estimated as sufficient for the operation of two kinds of waveguide-containing transducers.
AB - Covalent attachment of DNA molecules to the surface of silicon nitride without an intermediate polymer layer is described. It is shown that the silicon nitride has a sorption capacity no less than 200 pg/mm2, hybridization efficiency being close to 100%. The expected value of refractive index changes in the molecular layer under hybridization is estimated as sufficient for the operation of two kinds of waveguide-containing transducers.
KW - DNA fixation
KW - Molecular probe biosensor
KW - Optical waveguide sensors
UR - http://www.scopus.com/inward/record.url?scp=0029388386&partnerID=8YFLogxK
U2 - 10.1016/0925-4005(95)01701-1
DO - 10.1016/0925-4005(95)01701-1
M3 - Article
AN - SCOPUS:0029388386
VL - 29
SP - 324
EP - 327
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
IS - 1-3
ER -
ID: 96689032