Research output: Contribution to journal › Article › peer-review
First Insight into the Neuroprotective and Antibacterial Effects of Phlorotannins Isolated from the Cell Walls of Brown Algae Fucus vesiculosus and Pelvetia canaliculata. / Meshalkina, Darya; Tsvetkova, Elena; Orlova, Anastasia; Islamova, Renata; Grashina, Maria; Gorbach, Daria; Babakov, Vladimir; Francioso, Antonio; Birkemeyer, Claudia; Mosca, Luciana; Tarakhovskaya, Elena; Frolov, Andrej.
In: Antioxidants, Vol. 12, No. 3, 696, 11.03.2023.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - First Insight into the Neuroprotective and Antibacterial Effects of Phlorotannins Isolated from the Cell Walls of Brown Algae Fucus vesiculosus and Pelvetia canaliculata
AU - Meshalkina, Darya
AU - Tsvetkova, Elena
AU - Orlova, Anastasia
AU - Islamova, Renata
AU - Grashina, Maria
AU - Gorbach, Daria
AU - Babakov, Vladimir
AU - Francioso, Antonio
AU - Birkemeyer, Claudia
AU - Mosca, Luciana
AU - Tarakhovskaya, Elena
AU - Frolov, Andrej
PY - 2023/3/11
Y1 - 2023/3/11
N2 - Phaeophyceae (brown algae) essentially contribute to biotopes of cold and temperate seas. Their thalli are rich in biologically active natural products, which are strongly and universally dominated with phlorotannins-polyphenols of complex and diverse structure based on multiple differently arranged phloroglucinol units and well known as strong antioxidants with a broad spectrum of biological activities. In the algal cells, phlorotannins can either accumulate in the cytoplasm or can be secreted into the cell wall (CW). The biological activities of extractable intracellular phlorotannins have been comprehensively characterized, whereas the properties of the CW-bound polyphenol fraction are still mostly unknown. Recently, we identified dibenzodioxin bonding as the principal structural feature of the CW-bound phlorotannins in fucoid algae, whereas soluble intracellular phlorotannins rely on aryl and ether bonds. However, profiles of biological activity associated with these structural differences are still unknown. Therefore, to the best of our knowledge, for the first time we address the antioxidant, cytotoxic, neuroprotective, and antibacterial properties of the CW-bound phlorotannin fractions isolated from two representatives of the order Fucales-Fucus vesiculosus and Pelvetia canaliculata. The CW-bound phlorotannins appeared to be softer antioxidants, stronger antibacterial agents and were featured with essentially less cytotoxicity in comparison to the intracellular fraction. However, the neuroprotective effects of both sub-cellular phlorotannin fractions of F. vesiculosus and P. canaliculata were similar. Thus, due to their lower cytotoxicity, CW-bound phlorotannins can be considered as promising antioxidants and neuroprotectors.
AB - Phaeophyceae (brown algae) essentially contribute to biotopes of cold and temperate seas. Their thalli are rich in biologically active natural products, which are strongly and universally dominated with phlorotannins-polyphenols of complex and diverse structure based on multiple differently arranged phloroglucinol units and well known as strong antioxidants with a broad spectrum of biological activities. In the algal cells, phlorotannins can either accumulate in the cytoplasm or can be secreted into the cell wall (CW). The biological activities of extractable intracellular phlorotannins have been comprehensively characterized, whereas the properties of the CW-bound polyphenol fraction are still mostly unknown. Recently, we identified dibenzodioxin bonding as the principal structural feature of the CW-bound phlorotannins in fucoid algae, whereas soluble intracellular phlorotannins rely on aryl and ether bonds. However, profiles of biological activity associated with these structural differences are still unknown. Therefore, to the best of our knowledge, for the first time we address the antioxidant, cytotoxic, neuroprotective, and antibacterial properties of the CW-bound phlorotannin fractions isolated from two representatives of the order Fucales-Fucus vesiculosus and Pelvetia canaliculata. The CW-bound phlorotannins appeared to be softer antioxidants, stronger antibacterial agents and were featured with essentially less cytotoxicity in comparison to the intracellular fraction. However, the neuroprotective effects of both sub-cellular phlorotannin fractions of F. vesiculosus and P. canaliculata were similar. Thus, due to their lower cytotoxicity, CW-bound phlorotannins can be considered as promising antioxidants and neuroprotectors.
KW - Alzheimer’s disease
KW - Parkinson’s disease
KW - Phaeophyceae
KW - anti-neurodegenerative
KW - antibacterial
KW - antioxidant
KW - brown algae
KW - cell culture
KW - cell wall-bound phlorotannins
KW - neuroprotective
KW - phlorotannins
UR - https://www.mendeley.com/catalogue/6afb4c5a-0205-3dab-9412-b53df63c88e7/
U2 - 10.3390/antiox12030696
DO - 10.3390/antiox12030696
M3 - Article
C2 - 36978944
VL - 12
JO - Antioxidants
JF - Antioxidants
SN - 2076-3921
IS - 3
M1 - 696
ER -
ID: 107413157