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First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself. / Сказина, Мария Александровна; Одинцова, Нелия Адольфовна; Майорова, Мария; Иванова, Ангелина Витальевна; Väinölä, R.; Стрелков, Петр Петрович.

In: Scientific Reports, Vol. 11, No. 1, 5809, 12.2021.

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Сказина, Мария Александровна ; Одинцова, Нелия Адольфовна ; Майорова, Мария ; Иванова, Ангелина Витальевна ; Väinölä, R. ; Стрелков, Петр Петрович. / First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself. In: Scientific Reports. 2021 ; Vol. 11, No. 1.

BibTeX

@article{7246c45250eb4c49bec7f490031dc59c,
title = "First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself",
abstract = "Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus from the Northeast Pacific, while BTN2 has been detected in populations of other Mytilus species worldwide but not in M. trossulus itself. Here we examined M. trossulus from the Sea of Japan (Northwest Pacific) for the presence of BTN. Using hemocytology and flow cytometry of the hemolymph, we confirmed the presence of disseminated neoplasia in our specimens. Cancerous mussels possessed the BTN2 EF1α genotype and two mitochondrial haplotypes with different recombinant control regions, similar to that of common BTN2 lineages. This is the first report of BTN2 in its original host species M. trossulus. A comparison of all available BTN and M. trossulus COI sequences suggests a common and recent origin of BTN2 diversity in populations of M. trossulus outside the Northeast Pacific, possibly in the Northwest Pacific.",
keywords = "Animals, Base Sequence, Female, Haplotypes/genetics, Hemocytes/pathology, Male, Mytilus/classification, Neoplasms/pathology, Phylogeny, Species Specificity",
author = "Сказина, {Мария Александровна} and Одинцова, {Нелия Адольфовна} and Мария Майорова and Иванова, {Ангелина Витальевна} and R. V{\"a}in{\"o}l{\"a} and Стрелков, {Петр Петрович}",
year = "2021",
month = dec,
doi = "10.1038/s41598-021-85098-5",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself

AU - Сказина, Мария Александровна

AU - Одинцова, Нелия Адольфовна

AU - Майорова, Мария

AU - Иванова, Ангелина Витальевна

AU - Väinölä, R.

AU - Стрелков, Петр Петрович

PY - 2021/12

Y1 - 2021/12

N2 - Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus from the Northeast Pacific, while BTN2 has been detected in populations of other Mytilus species worldwide but not in M. trossulus itself. Here we examined M. trossulus from the Sea of Japan (Northwest Pacific) for the presence of BTN. Using hemocytology and flow cytometry of the hemolymph, we confirmed the presence of disseminated neoplasia in our specimens. Cancerous mussels possessed the BTN2 EF1α genotype and two mitochondrial haplotypes with different recombinant control regions, similar to that of common BTN2 lineages. This is the first report of BTN2 in its original host species M. trossulus. A comparison of all available BTN and M. trossulus COI sequences suggests a common and recent origin of BTN2 diversity in populations of M. trossulus outside the Northeast Pacific, possibly in the Northwest Pacific.

AB - Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus from the Northeast Pacific, while BTN2 has been detected in populations of other Mytilus species worldwide but not in M. trossulus itself. Here we examined M. trossulus from the Sea of Japan (Northwest Pacific) for the presence of BTN. Using hemocytology and flow cytometry of the hemolymph, we confirmed the presence of disseminated neoplasia in our specimens. Cancerous mussels possessed the BTN2 EF1α genotype and two mitochondrial haplotypes with different recombinant control regions, similar to that of common BTN2 lineages. This is the first report of BTN2 in its original host species M. trossulus. A comparison of all available BTN and M. trossulus COI sequences suggests a common and recent origin of BTN2 diversity in populations of M. trossulus outside the Northeast Pacific, possibly in the Northwest Pacific.

KW - Animals

KW - Base Sequence

KW - Female

KW - Haplotypes/genetics

KW - Hemocytes/pathology

KW - Male

KW - Mytilus/classification

KW - Neoplasms/pathology

KW - Phylogeny

KW - Species Specificity

UR - http://www.scopus.com/inward/record.url?scp=85102453310&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/7224ffdf-cb40-3c38-a86d-2d91b3a0c75d/

U2 - 10.1038/s41598-021-85098-5

DO - 10.1038/s41598-021-85098-5

M3 - Article

C2 - 33707525

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 5809

ER -

ID: 74938274