TY - JOUR

T1 - Fe3O4@HAp core–shell nanoparticles as MRI contrast agent: Synthesis, characterization and theoretical and experimental study of shell impact on magnetic properties

AU - Zheltova, Victoriya

AU - Vlasova, Anna

AU - Bobrysheva, Natalia

AU - Abdullin, Ilgiz

AU - Semenov, Valentin

AU - Osmolowsky, Mikhail

AU - Voznesenskiy, Mikhail

AU - Osmolovskaya, Olga

PY - 2020/11/30

Y1 - 2020/11/30

N2 - Magnetic core–shell Fe 3O 4@HAp nanoparticles (NPs) with a different HAp amount were synthesized using an original approach based on co-precipitation method combined with hydrothermal treatment (HTT) at temperatures range from 140 to 240 °C. NP morphological parameters were characterized using X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR), transmission electronic microscopy (TEM), specific surface area estimation (SSA), Mossbauer spectroscopy. As-prepared core–shell NPs are characterized by a narrow size distribution and the presence of magnetite and hydroxyapatite phase was shown. The trend of HAp amount – shell thickness dependence rely on HTT conditions which is probably due to the acceleration of crystallization process rate at higher temperatures. Core-shell NPs obtained at low temperatures possess a uniform shell with equal crystallinity and were further under study. The saturation magnetization of core–shell NPs is linearly decreasing with the increase of HAp amount from 68 emu/g (bare Fe 3O 4 core) to 52 emu/g (Fe 3O 4@20HAp). All the samples exhibited superparamagnetic behavior, the blocking temperature linear dependence on shell thickness was demonstrated. Computer simulation of blocking temperature dependence on shell thickness revealed the impact of the shell on the anisotropy constant and consequently on blocking temperature. To evaluate the efficiency of the core–shell NPs as contrast agents for magnetic resonance imaging (MRI), the samples with different HAp amount in agarose matrix were investigated. Images obtained with core–shell NPs are insignificantly less dark comparing with images obtained with bare NPs, but a higher value of T 2/T 1 ratio was achieved. Therefore, it can be concluded that as-prepared magnetic core–shell Fe 3O 4@HAp NPs can be considered as an effective contrast agent for MRI applications.

AB - Magnetic core–shell Fe 3O 4@HAp nanoparticles (NPs) with a different HAp amount were synthesized using an original approach based on co-precipitation method combined with hydrothermal treatment (HTT) at temperatures range from 140 to 240 °C. NP morphological parameters were characterized using X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR), transmission electronic microscopy (TEM), specific surface area estimation (SSA), Mossbauer spectroscopy. As-prepared core–shell NPs are characterized by a narrow size distribution and the presence of magnetite and hydroxyapatite phase was shown. The trend of HAp amount – shell thickness dependence rely on HTT conditions which is probably due to the acceleration of crystallization process rate at higher temperatures. Core-shell NPs obtained at low temperatures possess a uniform shell with equal crystallinity and were further under study. The saturation magnetization of core–shell NPs is linearly decreasing with the increase of HAp amount from 68 emu/g (bare Fe 3O 4 core) to 52 emu/g (Fe 3O 4@20HAp). All the samples exhibited superparamagnetic behavior, the blocking temperature linear dependence on shell thickness was demonstrated. Computer simulation of blocking temperature dependence on shell thickness revealed the impact of the shell on the anisotropy constant and consequently on blocking temperature. To evaluate the efficiency of the core–shell NPs as contrast agents for magnetic resonance imaging (MRI), the samples with different HAp amount in agarose matrix were investigated. Images obtained with core–shell NPs are insignificantly less dark comparing with images obtained with bare NPs, but a higher value of T 2/T 1 ratio was achieved. Therefore, it can be concluded that as-prepared magnetic core–shell Fe 3O 4@HAp NPs can be considered as an effective contrast agent for MRI applications.

KW - Computer simulation

KW - Core-shell Nanoparticles

KW - Fe O

KW - Hydroxyapatite

KW - MRI

KW - Magnetic materials

KW - Fe3O4

KW - COATED FE3O4 NANOPARTICLES

KW - NANOCOMPOSITE

KW - FACILE

UR - http://www.scopus.com/inward/record.url?scp=85088900118&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/e323de5f-0a50-3b11-8ced-502360ffb0f1/

U2 - https://doi.org/10.1016/j.apsusc.2020.147352

DO - https://doi.org/10.1016/j.apsusc.2020.147352

M3 - Article

VL - 531

JO - Applied Surface Science

JF - Applied Surface Science

SN - 0169-4332

M1 - 147352

ER -