Research output: Contribution to journal › Article › peer-review
Farmakokinetika galodifa pri razlichnoi prodolzhitel'nosti ego vvedeniia. / Kanov, E. V.; Novozheeva, T. P.; Saratikov, A. S.
In: Eksperimental'naia i klinicheskaia farmakologiia, Vol. 65, No. 2, 2002, p. 56-58.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Farmakokinetika galodifa pri razlichnoi prodolzhitel'nosti ego vvedeniia.
AU - Kanov, E. V.
AU - Novozheeva, T. P.
AU - Saratikov, A. S.
PY - 2002
Y1 - 2002
N2 - Pharmacokinetics of the new antiepileptic drug galodif was experimentally studied on rats. A single administration of the anticonvulsant is followed by slow elimination. A five-day administration leads to a significant acceleration of the drug elimination due to activation of the cytochrome P-450 dependent monooxygenase system of liver. After a 14-day administration, the elimination rate decreases as compared to that for the five-day treatment, while being still higher than in the case of single administration.
AB - Pharmacokinetics of the new antiepileptic drug galodif was experimentally studied on rats. A single administration of the anticonvulsant is followed by slow elimination. A five-day administration leads to a significant acceleration of the drug elimination due to activation of the cytochrome P-450 dependent monooxygenase system of liver. After a 14-day administration, the elimination rate decreases as compared to that for the five-day treatment, while being still higher than in the case of single administration.
UR - http://www.scopus.com/inward/record.url?scp=0036490937&partnerID=8YFLogxK
M3 - статья
C2 - 12109296
AN - SCOPUS:0036490937
VL - 65
SP - 56
EP - 58
JO - ЭКСПЕРИМЕНТАЛЬНАЯ И КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯ
JF - ЭКСПЕРИМЕНТАЛЬНАЯ И КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯ
SN - 0869-2092
IS - 2
ER -
ID: 99966910