Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids

Research output: Contribution to journal › Article › peer-review

Department of Physical Organic Chemistry

DOI

https://doi.org/10.1016/j.tetlet.2018.06.019
Final published version

Татьяна Шаронова
Виталина Панкратьева
Полина Савко
Сергей Валентинович Байков
Антон Шетнев

A one-pot ambient-temperature procedure for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from amidoximes and carboxylic acids under superbase-promoted conditions is reported.

Original language	English
Pages (from-to)	2824-2827
Number of pages	4
Journal	Tetrahedron Letters
Volume	59
Issue number	29
DOIs	https://doi.org/10.1016/j.tetlet.2018.06.019
State	Published - 18 Jul 2018

Scopus subject areas

Organic Chemistry
Drug Discovery
Biochemistry

Research areas

Amidoximes, Carboxylic acids, Heterocycles, Room temperature synthesis, Superbase promoted, ACTIVATION, RINGS, OXADIAZOLE DERIVATIVES, COUPLING REAGENTS, DISCOVERY, ACTIVITY-RELATIONSHIP SAR, INHIBITORS, OXIDATIVE CYCLIZATION, EFFICIENT, PARALLEL SYNTHESIS

ID: 28372282