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Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy. / Khudiakov, A. A.; Smolina, N. A.; Perepelina, K. I.; Malashicheva, A. B.; Kostareva, A. A.

In: Biochemistry (Moscow), Vol. 84, No. 3, 01.03.2019, p. 272-282.

Research output: Contribution to journal › Article › peer-review

Harvard

Khudiakov, AA, Smolina, NA, Perepelina, KI, Malashicheva, AB & Kostareva, AA 2019, 'Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy', Biochemistry (Moscow), vol. 84, no. 3, pp. 272-282. https://doi.org/10.1134/S000629791903009X

APA

Khudiakov, A. A., Smolina, N. A., Perepelina, K. I., Malashicheva, A. B., & Kostareva, A. A. (2019). Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy. Biochemistry (Moscow), 84(3), 272-282. https://doi.org/10.1134/S000629791903009X

Vancouver

Khudiakov AA, Smolina NA, Perepelina KI, Malashicheva AB, Kostareva AA. Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy. Biochemistry (Moscow). 2019 Mar 1;84(3):272-282. https://doi.org/10.1134/S000629791903009X

Author

Khudiakov, A. A. ; Smolina, N. A. ; Perepelina, K. I. ; Malashicheva, A. B. ; Kostareva, A. A. / Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy. In: Biochemistry (Moscow). 2019 ; Vol. 84, No. 3. pp. 272-282.

BibTeX

@article{4e8022f4996847da8d9c413eadb21b90,
title = "Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy",
abstract = "Differential diagnosis of arrhythmogenic cardiomyopathy (ACM) during the disease latent phase is a challenging clinical problem that requires identification of early ACM biomarkers. Because extracellular nucleic acids are stable, specific, and can be easily detected, they can be used as reliable biomarkers of various diseases. In this study, we analyzed the levels of extracellular microRNAs and mitochondrial DNA in the conditioned medium collected from cardiomyocytes differentiated from induced pluripotent stem cells of ACM patients and healthy donor. Several microRNAs were expressed differently by the affected and healthy cardiomyocytes; therefore, they could be considered as potential ACM biomarkers.",
keywords = "arrhythmogenic cardiomyopathy, cardiomyocytes, induced pluripotent stem cells, microRNA, mitochondrial DNA",
author = "Khudiakov, {A. A.} and Smolina, {N. A.} and Perepelina, {K. I.} and Malashicheva, {A. B.} and Kostareva, {A. A.}",
year = "2019",
month = mar,
day = "1",
doi = "10.1134/S000629791903009X",
language = "English",
volume = "84",
pages = "272--282",
journal = "Biochemistry (Moscow)",
issn = "0006-2979",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "3",

}

RIS

TY - JOUR

T1 - Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy

AU - Khudiakov, A. A.

AU - Smolina, N. A.

AU - Perepelina, K. I.

AU - Malashicheva, A. B.

AU - Kostareva, A. A.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Differential diagnosis of arrhythmogenic cardiomyopathy (ACM) during the disease latent phase is a challenging clinical problem that requires identification of early ACM biomarkers. Because extracellular nucleic acids are stable, specific, and can be easily detected, they can be used as reliable biomarkers of various diseases. In this study, we analyzed the levels of extracellular microRNAs and mitochondrial DNA in the conditioned medium collected from cardiomyocytes differentiated from induced pluripotent stem cells of ACM patients and healthy donor. Several microRNAs were expressed differently by the affected and healthy cardiomyocytes; therefore, they could be considered as potential ACM biomarkers.

AB - Differential diagnosis of arrhythmogenic cardiomyopathy (ACM) during the disease latent phase is a challenging clinical problem that requires identification of early ACM biomarkers. Because extracellular nucleic acids are stable, specific, and can be easily detected, they can be used as reliable biomarkers of various diseases. In this study, we analyzed the levels of extracellular microRNAs and mitochondrial DNA in the conditioned medium collected from cardiomyocytes differentiated from induced pluripotent stem cells of ACM patients and healthy donor. Several microRNAs were expressed differently by the affected and healthy cardiomyocytes; therefore, they could be considered as potential ACM biomarkers.

KW - arrhythmogenic cardiomyopathy

KW - cardiomyocytes

KW - induced pluripotent stem cells

KW - microRNA

KW - mitochondrial DNA

UR - http://www.scopus.com/inward/record.url?scp=85063504848&partnerID=8YFLogxK

U2 - 10.1134/S000629791903009X

DO - 10.1134/S000629791903009X

M3 - Article

AN - SCOPUS:85063504848

VL - 84

SP - 272

EP - 282

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - 3

ER -

ID: 42536474