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Expression pattern of Filamin-240 in Drosophila blood cells. / Rus, Florentina; Kurucz, Éva; Márkus, Róbert; Sinenko, Sergey A.; Laurinyecz, Barbara; Pataki, Csilla; Gausz, János; Hegedus, Zoltán; Udvardy, Andor; Hultmark, Dan; Andó, István.

In: Gene Expression Patterns, Vol. 6, No. 8, 02.10.2006, p. 928-934.

Research output: Contribution to journal › Article › peer-review

Harvard

Rus, F, Kurucz, É, Márkus, R, Sinenko, SA, Laurinyecz, B, Pataki, C, Gausz, J, Hegedus, Z, Udvardy, A, Hultmark, D & Andó, I 2006, 'Expression pattern of Filamin-240 in Drosophila blood cells', Gene Expression Patterns, vol. 6, no. 8, pp. 928-934. https://doi.org/10.1016/j.modgep.2006.03.005

APA

Rus, F., Kurucz, É., Márkus, R., Sinenko, S. A., Laurinyecz, B., Pataki, C., Gausz, J., Hegedus, Z., Udvardy, A., Hultmark, D., & Andó, I. (2006). Expression pattern of Filamin-240 in Drosophila blood cells. Gene Expression Patterns, 6(8), 928-934. https://doi.org/10.1016/j.modgep.2006.03.005

Vancouver

Rus F, Kurucz É, Márkus R, Sinenko SA, Laurinyecz B, Pataki C et al. Expression pattern of Filamin-240 in Drosophila blood cells. Gene Expression Patterns. 2006 Oct 2;6(8):928-934. https://doi.org/10.1016/j.modgep.2006.03.005

Author

Rus, Florentina ; Kurucz, Éva ; Márkus, Róbert ; Sinenko, Sergey A. ; Laurinyecz, Barbara ; Pataki, Csilla ; Gausz, János ; Hegedus, Zoltán ; Udvardy, Andor ; Hultmark, Dan ; Andó, István. / Expression pattern of Filamin-240 in Drosophila blood cells. In: Gene Expression Patterns. 2006 ; Vol. 6, No. 8. pp. 928-934.

BibTeX

@article{b25a642abed049508e6f249c31af8c54,
title = "Expression pattern of Filamin-240 in Drosophila blood cells",
abstract = "The expression pattern of Filamin-240 was studied in subsets of Drosophila blood cells by means of immunofluorescent staining and Western blot analysis with use of an antibody specific to a {"}filamin-folding domain{"}, a consensus motif profile generated from the 20 existing filamin repeats. Expression of Filamin-240 is restricted to lamellocytes - a special blood cell type of the cellular immune response - and is involved in the regulation of lamellocyte development. In the cher1 homozygous larvae, which lack Filamin-240 protein, a vigorous lamellocyte differentiation occurs which is further enhanced upon in vivo immune challenge by a parasitic wasp, Leptopilina boulardi. By introducing a full-length transgene encoding the Drosophila Filamin-240 protein into the cher1 Filamin-deficient homozygous mutant, the mutant blood cell phenotype was rescued. These data demonstrate that the expression of Filamin-240 is strictly lamellocyte specific in Drosophila blood cells and that the protein is a suppressor of lamellocyte development.",
keywords = "Actin network, Blood cell, Blood cell development, Drosophila, Encapsulation, Filamin, Hemocyte, Immune induction, Lamellocyte",
author = "Florentina Rus and {\'E}va Kurucz and R{\'o}bert M{\'a}rkus and Sinenko, {Sergey A.} and Barbara Laurinyecz and Csilla Pataki and J{\'a}nos Gausz and Zolt{\'a}n Hegedus and Andor Udvardy and Dan Hultmark and Istv{\'a}n And{\'o}",
year = "2006",
month = oct,
day = "2",
doi = "10.1016/j.modgep.2006.03.005",
language = "English",
volume = "6",
pages = "928--934",
journal = "Gene Expression Patterns",
issn = "1567-133X",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Expression pattern of Filamin-240 in Drosophila blood cells

AU - Rus, Florentina

AU - Kurucz, Éva

AU - Márkus, Róbert

AU - Sinenko, Sergey A.

AU - Laurinyecz, Barbara

AU - Pataki, Csilla

AU - Gausz, János

AU - Hegedus, Zoltán

AU - Udvardy, Andor

AU - Hultmark, Dan

AU - Andó, István

PY - 2006/10/2

Y1 - 2006/10/2

N2 - The expression pattern of Filamin-240 was studied in subsets of Drosophila blood cells by means of immunofluorescent staining and Western blot analysis with use of an antibody specific to a "filamin-folding domain", a consensus motif profile generated from the 20 existing filamin repeats. Expression of Filamin-240 is restricted to lamellocytes - a special blood cell type of the cellular immune response - and is involved in the regulation of lamellocyte development. In the cher1 homozygous larvae, which lack Filamin-240 protein, a vigorous lamellocyte differentiation occurs which is further enhanced upon in vivo immune challenge by a parasitic wasp, Leptopilina boulardi. By introducing a full-length transgene encoding the Drosophila Filamin-240 protein into the cher1 Filamin-deficient homozygous mutant, the mutant blood cell phenotype was rescued. These data demonstrate that the expression of Filamin-240 is strictly lamellocyte specific in Drosophila blood cells and that the protein is a suppressor of lamellocyte development.

AB - The expression pattern of Filamin-240 was studied in subsets of Drosophila blood cells by means of immunofluorescent staining and Western blot analysis with use of an antibody specific to a "filamin-folding domain", a consensus motif profile generated from the 20 existing filamin repeats. Expression of Filamin-240 is restricted to lamellocytes - a special blood cell type of the cellular immune response - and is involved in the regulation of lamellocyte development. In the cher1 homozygous larvae, which lack Filamin-240 protein, a vigorous lamellocyte differentiation occurs which is further enhanced upon in vivo immune challenge by a parasitic wasp, Leptopilina boulardi. By introducing a full-length transgene encoding the Drosophila Filamin-240 protein into the cher1 Filamin-deficient homozygous mutant, the mutant blood cell phenotype was rescued. These data demonstrate that the expression of Filamin-240 is strictly lamellocyte specific in Drosophila blood cells and that the protein is a suppressor of lamellocyte development.

KW - Actin network

KW - Blood cell

KW - Blood cell development

KW - Drosophila

KW - Encapsulation

KW - Filamin

KW - Hemocyte

KW - Immune induction

KW - Lamellocyte

UR - http://www.scopus.com/inward/record.url?scp=33748306322&partnerID=8YFLogxK

U2 - 10.1016/j.modgep.2006.03.005

DO - 10.1016/j.modgep.2006.03.005

M3 - Article

C2 - 16616709

AN - SCOPUS:33748306322

VL - 6

SP - 928

EP - 934

JO - Gene Expression Patterns

JF - Gene Expression Patterns

SN - 1567-133X

IS - 8

ER -

ID: 50502145