Research output: Contribution to journal › Article › peer-review
Expression of thrombospondin-1 gene mRNA and protein in the placenta in gestosis. / Ostankova, Yu V.; Klimovskaya, Ya S.; Gorskaya, O. A.; Kolobov, A. V.; Kvetnoi, I. M.; Selkov, S. A.; Sokolov, D. I.
In: Bulletin of Experimental Biology and Medicine, Vol. 151, No. 2, 01.06.2011, p. 215-218.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Expression of thrombospondin-1 gene mRNA and protein in the placenta in gestosis
AU - Ostankova, Yu V.
AU - Klimovskaya, Ya S.
AU - Gorskaya, O. A.
AU - Kolobov, A. V.
AU - Kvetnoi, I. M.
AU - Selkov, S. A.
AU - Sokolov, D. I.
PY - 2011/6/1
Y1 - 2011/6/1
N2 - The expression of TSP-1 gene mRNA and TSP-1 protein in the placental tissue was studied during normal pregnancy and in gestosis. The formation of placental tissue in normal gestation was associated with expression of TSP-1 gene mRNA and of TSP-1 protein. Gestosis was associated with infl ammatory reaction in the placenta characterized by increased counts of lymphocytes and macrophages in the villous stroma and involution degenerative changes in tissue. Disorders in placental villi maturation and branching in gestosis were paralleled by hyperexpression of TSP-1 gene mRNA by placental cells and hyperexpression of TSP-1 protein predominating in the stromal elements of terminal villi and near villous vessels.
AB - The expression of TSP-1 gene mRNA and TSP-1 protein in the placental tissue was studied during normal pregnancy and in gestosis. The formation of placental tissue in normal gestation was associated with expression of TSP-1 gene mRNA and of TSP-1 protein. Gestosis was associated with infl ammatory reaction in the placenta characterized by increased counts of lymphocytes and macrophages in the villous stroma and involution degenerative changes in tissue. Disorders in placental villi maturation and branching in gestosis were paralleled by hyperexpression of TSP-1 gene mRNA by placental cells and hyperexpression of TSP-1 protein predominating in the stromal elements of terminal villi and near villous vessels.
KW - angiogenesis
KW - gestosis
KW - macrophages
KW - placenta
KW - thrombospondin
UR - http://www.scopus.com/inward/record.url?scp=79959541219&partnerID=8YFLogxK
U2 - 10.1007/s10517-011-1292-1
DO - 10.1007/s10517-011-1292-1
M3 - Article
C2 - 22238753
AN - SCOPUS:79959541219
VL - 151
SP - 215
EP - 218
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 2
ER -
ID: 48927950