Research output: Contribution to journal › Review article › peer-review
Exploring CNS effects of American traditional medicines using zebrafish models. / de Abreu, Murilo S; Costa, Fabiano; Giacomini, Ana C V V; Demin, Konstantin A; Petersen, Elena V; Rosemberg, Denis B; Kalueff, Allan V.
In: Current Neuropharmacology, Vol. 20, No. 3, 12.07.2021, p. 550-559.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Exploring CNS effects of American traditional medicines using zebrafish models
AU - de Abreu, Murilo S
AU - Costa, Fabiano
AU - Giacomini, Ana C V V
AU - Demin, Konstantin A
AU - Petersen, Elena V
AU - Rosemberg, Denis B
AU - Kalueff, Allan V
N1 - Publisher Copyright: © 2022 Bentham Science Publishers.
PY - 2021/7/12
Y1 - 2021/7/12
N2 - Although American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.
AB - Although American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.
KW - American traditional medicine
KW - Animal models
KW - Behavior
KW - Brain effects
KW - Drug screening
KW - Zebrafish
KW - Neurosciences
KW - Animals
KW - Neuropharmacology
KW - Medicine, Traditional
KW - Disease Models, Animal
UR - https://www.mendeley.com/catalogue/6edb8426-9246-3eeb-a62a-5425988476b1/
UR - http://www.scopus.com/inward/record.url?scp=85126830478&partnerID=8YFLogxK
U2 - 10.2174/1570159x19666210712153329
DO - 10.2174/1570159x19666210712153329
M3 - Review article
C2 - 34254921
VL - 20
SP - 550
EP - 559
JO - Current Neuropharmacology
JF - Current Neuropharmacology
SN - 1570-159X
IS - 3
ER -
ID: 83920372