TY - JOUR

T1 - Experimental models of human cortical malformations: from mammals to 'acortical' zebrafish

AU - Costa, Fabiano V.

AU - Забегалов, Константин Николаевич

AU - Колесникова, Татьяна Олеговна

AU - de Abreu, Murillo

AU - Котова, Мария Михайловна

AU - Petersen, Elena

AU - Калуев, Алан Валерьевич

PY - 2023/12/1

Y1 - 2023/12/1

N2 - Human neocortex controls and integrates cognition, emotions, perception and complex behaviors. Aberrant cortical development can be triggered by multiple genetic and environmental factors, causing cortical malformations. Animal models, especially rodents, are a valuable tool to probe molecular and physiological mechanisms of cortical malformations. Complementing rodent studies, the zebrafish (Danio rerio) is an important model organism in biomedicine. Although the zebrafish (like other fishes) lacks neocortex, here we argue that this species can still be used to model various aspects and brain phenomena related to human cortical malformations. We also discuss novel perspectives in this field, covering both advantages and limitations of using mammalian and zebrafish models in cortical malformation research. Summarizing mounting evidence, we also highlight the importance of translationally-relevant insights into the pathogenesis of cortical malformations from animal models, and discuss future strategies of research in the field.

AB - Human neocortex controls and integrates cognition, emotions, perception and complex behaviors. Aberrant cortical development can be triggered by multiple genetic and environmental factors, causing cortical malformations. Animal models, especially rodents, are a valuable tool to probe molecular and physiological mechanisms of cortical malformations. Complementing rodent studies, the zebrafish (Danio rerio) is an important model organism in biomedicine. Although the zebrafish (like other fishes) lacks neocortex, here we argue that this species can still be used to model various aspects and brain phenomena related to human cortical malformations. We also discuss novel perspectives in this field, covering both advantages and limitations of using mammalian and zebrafish models in cortical malformation research. Summarizing mounting evidence, we also highlight the importance of translationally-relevant insights into the pathogenesis of cortical malformations from animal models, and discuss future strategies of research in the field.

KW - Animal model

KW - Cortex

KW - Cortical malformation

KW - Zebrafish

UR - https://www.mendeley.com/catalogue/f988580e-335c-3606-a4f9-223d4a01a515/

U2 - 10.1016/j.neubiorev.2023.105429

DO - 10.1016/j.neubiorev.2023.105429

M3 - Article

VL - 155

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

M1 - 105429

ER -