Examination and optimization of the self-assembly of biocompatible, polymeric nanoparticles by high-throughput nanoprecipitation

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Examination and optimization of the self-assembly of biocompatible, polymeric nanoparticles by high-throughput nanoprecipitation. / Perevyazko, Igor Y.; Delaney, Joseph T.; Vollrath, Antje; Pavlov, Georges M.; Schubert, Stephanie; Schubert, Ulrich S.

In: Soft Matter, Vol. 7, No. 10, 21.05.2011, p. 5030-5035.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{5af76ab75acb46f9973a8e00875c2290,

title = "Examination and optimization of the self-assembly of biocompatible, polymeric nanoparticles by high-throughput nanoprecipitation",

abstract = "In recent years, the development of polymer nanoparticle suspensions by nanoprecipitation has gained increased attention both by industry and academia. However, the process by which such formulations are prepared is a highly empirically driven enterprise, whereby developing optimized formulations remains an iterative process. In this contribution, a new approach towards exploration of the materials space for these systems is reported, based on systematically varying processing and formulation to understand their influence on the characteristics of the resulting materials. Taking advantage of the tools and techniques that have already been standardized by informatics-driven life sciences disciplines, we have prepared libraries of nanoparticle formulations of poly(methyl methacrylate-stat-acrylate), poly(lactic-co-glycolic acid), and acetal-derivatized dextran by using a pipetting robot. They were subsequently characterized using a dynamic light scattering plate reader, analytical ultracentrifugation, and scanning electron microscopy. With this high-throughput nanoprecipitation approach, large numbers of materials can be prepared, screened, and the formulation rationally optimized. {\textcopyright} 2011 The Royal Society of Chemistry.",

author = "Perevyazko, {Igor Y.} and Delaney, {Joseph T.} and Antje Vollrath and Pavlov, {Georges M.} and Stephanie Schubert and Schubert, {Ulrich S.}",

year = "2011",

month = may,

day = "21",

doi = "10.1039/c1sm05079f",

language = "English",

volume = "7",

pages = "5030--5035",

journal = "Soft Matter",

issn = "1744-683X",

publisher = "Royal Society of Chemistry",

number = "10",

}

RIS

TY - JOUR

T1 - Examination and optimization of the self-assembly of biocompatible, polymeric nanoparticles by high-throughput nanoprecipitation

AU - Perevyazko, Igor Y.

AU - Delaney, Joseph T.

AU - Vollrath, Antje

AU - Pavlov, Georges M.

AU - Schubert, Stephanie

AU - Schubert, Ulrich S.

PY - 2011/5/21

Y1 - 2011/5/21

N2 - In recent years, the development of polymer nanoparticle suspensions by nanoprecipitation has gained increased attention both by industry and academia. However, the process by which such formulations are prepared is a highly empirically driven enterprise, whereby developing optimized formulations remains an iterative process. In this contribution, a new approach towards exploration of the materials space for these systems is reported, based on systematically varying processing and formulation to understand their influence on the characteristics of the resulting materials. Taking advantage of the tools and techniques that have already been standardized by informatics-driven life sciences disciplines, we have prepared libraries of nanoparticle formulations of poly(methyl methacrylate-stat-acrylate), poly(lactic-co-glycolic acid), and acetal-derivatized dextran by using a pipetting robot. They were subsequently characterized using a dynamic light scattering plate reader, analytical ultracentrifugation, and scanning electron microscopy. With this high-throughput nanoprecipitation approach, large numbers of materials can be prepared, screened, and the formulation rationally optimized. © 2011 The Royal Society of Chemistry.

AB - In recent years, the development of polymer nanoparticle suspensions by nanoprecipitation has gained increased attention both by industry and academia. However, the process by which such formulations are prepared is a highly empirically driven enterprise, whereby developing optimized formulations remains an iterative process. In this contribution, a new approach towards exploration of the materials space for these systems is reported, based on systematically varying processing and formulation to understand their influence on the characteristics of the resulting materials. Taking advantage of the tools and techniques that have already been standardized by informatics-driven life sciences disciplines, we have prepared libraries of nanoparticle formulations of poly(methyl methacrylate-stat-acrylate), poly(lactic-co-glycolic acid), and acetal-derivatized dextran by using a pipetting robot. They were subsequently characterized using a dynamic light scattering plate reader, analytical ultracentrifugation, and scanning electron microscopy. With this high-throughput nanoprecipitation approach, large numbers of materials can be prepared, screened, and the formulation rationally optimized. © 2011 The Royal Society of Chemistry.

UR - http://www.scopus.com/inward/record.url?scp=79955660964&partnerID=8YFLogxK

U2 - 10.1039/c1sm05079f

DO - 10.1039/c1sm05079f

M3 - Article

AN - SCOPUS:79955660964

VL - 7

SP - 5030

EP - 5035

JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

IS - 10

ER -

ID: 136110982