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Evolutionary origins of chemical synapses. / Ovsepian, Saak V.; O'Leary, Valerie B.; Vesselkin, Nikolai P.

Hormones and Synapse. ed. / Gerald Litwack. Elsevier, 2020. p. 1-21 (Vitamins and Hormones; Vol. 114).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Harvard

Ovsepian, SV, O'Leary, VB & Vesselkin, NP 2020, Evolutionary origins of chemical synapses. in G Litwack (ed.), Hormones and Synapse. Vitamins and Hormones, vol. 114, Elsevier, pp. 1-21. https://doi.org/10.1016/bs.vh.2020.04.009

APA

Ovsepian, S. V., O'Leary, V. B., & Vesselkin, N. P. (2020). Evolutionary origins of chemical synapses. In G. Litwack (Ed.), Hormones and Synapse (pp. 1-21). (Vitamins and Hormones; Vol. 114). Elsevier. https://doi.org/10.1016/bs.vh.2020.04.009

Vancouver

Ovsepian SV, O'Leary VB, Vesselkin NP. Evolutionary origins of chemical synapses. In Litwack G, editor, Hormones and Synapse. Elsevier. 2020. p. 1-21. (Vitamins and Hormones). https://doi.org/10.1016/bs.vh.2020.04.009

Author

Ovsepian, Saak V. ; O'Leary, Valerie B. ; Vesselkin, Nikolai P. / Evolutionary origins of chemical synapses. Hormones and Synapse. editor / Gerald Litwack. Elsevier, 2020. pp. 1-21 (Vitamins and Hormones).

BibTeX

@inbook{b0b7dc76ef2742a9ba84c07cbb919348,
title = "Evolutionary origins of chemical synapses",
abstract = "Synaptic transmission is a fundamental neurobiological process by which neurons interact with each other and non-neuronal cells. It involves release of active substances from the presynaptic neuron onto receptive elements of postsynaptic cells, inducing waves of spreading electrochemical response. While much has been learned about the cellular and molecular mechanisms driving and governing transmitter release and sensing, the evolutionary origin of synaptic connections remains obscure. Herein, we review emerging evidence and concepts suggesting that key components of chemical synapse arose independently from neurons, in different functional and biological contexts, before the rise of multicellular living forms. We argue that throughout evolution, distinct synaptic constituents have been co-opted from ancestral forms for a new role in early metazoan, leading to the rise of chemical synapses and neurotransmission. Such a mosaic model of the origin of chemical synapses agrees with and supports the pluralistic hypothesis of evolutionary change.",
keywords = "Chemical synapse, Exaptation, Functional integration, Gap junctions, Paracrine signaling, SNARE proteins, Synaptic evolution",
author = "Ovsepian, {Saak V.} and O'Leary, {Valerie B.} and Vesselkin, {Nikolai P.}",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
doi = "10.1016/bs.vh.2020.04.009",
language = "English",
isbn = "9780128220252",
series = "Vitamins and Hormones",
publisher = "Elsevier",
pages = "1--21",
editor = "Gerald Litwack",
booktitle = "Hormones and Synapse",
address = "Netherlands",

}

RIS

TY - CHAP

T1 - Evolutionary origins of chemical synapses

AU - Ovsepian, Saak V.

AU - O'Leary, Valerie B.

AU - Vesselkin, Nikolai P.

N1 - Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020

Y1 - 2020

N2 - Synaptic transmission is a fundamental neurobiological process by which neurons interact with each other and non-neuronal cells. It involves release of active substances from the presynaptic neuron onto receptive elements of postsynaptic cells, inducing waves of spreading electrochemical response. While much has been learned about the cellular and molecular mechanisms driving and governing transmitter release and sensing, the evolutionary origin of synaptic connections remains obscure. Herein, we review emerging evidence and concepts suggesting that key components of chemical synapse arose independently from neurons, in different functional and biological contexts, before the rise of multicellular living forms. We argue that throughout evolution, distinct synaptic constituents have been co-opted from ancestral forms for a new role in early metazoan, leading to the rise of chemical synapses and neurotransmission. Such a mosaic model of the origin of chemical synapses agrees with and supports the pluralistic hypothesis of evolutionary change.

AB - Synaptic transmission is a fundamental neurobiological process by which neurons interact with each other and non-neuronal cells. It involves release of active substances from the presynaptic neuron onto receptive elements of postsynaptic cells, inducing waves of spreading electrochemical response. While much has been learned about the cellular and molecular mechanisms driving and governing transmitter release and sensing, the evolutionary origin of synaptic connections remains obscure. Herein, we review emerging evidence and concepts suggesting that key components of chemical synapse arose independently from neurons, in different functional and biological contexts, before the rise of multicellular living forms. We argue that throughout evolution, distinct synaptic constituents have been co-opted from ancestral forms for a new role in early metazoan, leading to the rise of chemical synapses and neurotransmission. Such a mosaic model of the origin of chemical synapses agrees with and supports the pluralistic hypothesis of evolutionary change.

KW - Chemical synapse

KW - Exaptation

KW - Functional integration

KW - Gap junctions

KW - Paracrine signaling

KW - SNARE proteins

KW - Synaptic evolution

UR - http://www.scopus.com/inward/record.url?scp=85087395425&partnerID=8YFLogxK

U2 - 10.1016/bs.vh.2020.04.009

DO - 10.1016/bs.vh.2020.04.009

M3 - Chapter

C2 - 32723540

AN - SCOPUS:85087395425

SN - 9780128220252

T3 - Vitamins and Hormones

SP - 1

EP - 21

BT - Hormones and Synapse

A2 - Litwack, Gerald

PB - Elsevier

ER -

ID: 88553677