Evolutionarily conserved features of the retained intron in alternative transcripts of the nxf1 (nuclear export factor) genes in different organisms

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Evolutionarily conserved features of the retained intron in alternative transcripts of the nxf1 (nuclear export factor) genes in different organisms. / Mamon, Ludmila A.; Kliver, Sergey F.; Golubkova, Elena V.

In: Open Journal of Genetics, No. 3, 2013, p. 159-170.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{513db780e277401ebdff5d615c571ed5,

title = "Evolutionarily conserved features of the retained intron in alternative transcripts of the nxf1 (nuclear export factor) genes in different organisms",

abstract = "One of the features of intron-containing genes of the nxf (nuclear export factor) family in different organ- isms is the presence of an evolutionarily conserved exon-intron block: exon 110nt-intron-exon 37nt. The intron in this evolutionarily conserved block, which we call a “cassette” intron, can be excised or retained in alternative transcripts of nxf1. It corresponds to intron 10 - 11 in the genes that are orthologous to nxf1 in vertebrates, and intron 5 - 6 in the genes that are orthologous to nxf1 in Drosophilidae. The align- ment of sequences of cassette introns in nxf1 genes in vertebrates has revealed four evolutionarily con- served sequences: 1) 5{\textquoteright} flanking sequence, 2) a region containing СТЕ (constitutive transport element), 3) third conserved sequence, and 4) 3{\textquoteright} flanking sequence. Introns 5 - 6 of nxf1 in Drosophilidae have no similar conserved sequences. The results of sequence align- ment demonstrate a similarity between cassette in- trons of nxf1 in Drosophilidae in two poly(A) se- quences. The",

keywords = "Nxf, Intron Retention, CTE, Poly(A), Drosophila, Vertebrates",

author = "Mamon, {Ludmila A.} and Kliver, {Sergey F.} and Golubkova, {Elena V.}",

year = "2013",

doi = "10.4236/ojgen.2013.33018",

language = "English",

pages = "159--170",

journal = "Open Journal of Genetics",

issn = "2162-4453",

publisher = "Scientific Research",

number = "3",

}

RIS

TY - JOUR

T1 - Evolutionarily conserved features of the retained intron in alternative transcripts of the nxf1 (nuclear export factor) genes in different organisms

AU - Mamon, Ludmila A.

AU - Kliver, Sergey F.

AU - Golubkova, Elena V.

PY - 2013

Y1 - 2013

N2 - One of the features of intron-containing genes of the nxf (nuclear export factor) family in different organ- isms is the presence of an evolutionarily conserved exon-intron block: exon 110nt-intron-exon 37nt. The intron in this evolutionarily conserved block, which we call a “cassette” intron, can be excised or retained in alternative transcripts of nxf1. It corresponds to intron 10 - 11 in the genes that are orthologous to nxf1 in vertebrates, and intron 5 - 6 in the genes that are orthologous to nxf1 in Drosophilidae. The align- ment of sequences of cassette introns in nxf1 genes in vertebrates has revealed four evolutionarily con- served sequences: 1) 5’ flanking sequence, 2) a region containing СТЕ (constitutive transport element), 3) third conserved sequence, and 4) 3’ flanking sequence. Introns 5 - 6 of nxf1 in Drosophilidae have no similar conserved sequences. The results of sequence align- ment demonstrate a similarity between cassette in- trons of nxf1 in Drosophilidae in two poly(A) se- quences. The

AB - One of the features of intron-containing genes of the nxf (nuclear export factor) family in different organ- isms is the presence of an evolutionarily conserved exon-intron block: exon 110nt-intron-exon 37nt. The intron in this evolutionarily conserved block, which we call a “cassette” intron, can be excised or retained in alternative transcripts of nxf1. It corresponds to intron 10 - 11 in the genes that are orthologous to nxf1 in vertebrates, and intron 5 - 6 in the genes that are orthologous to nxf1 in Drosophilidae. The align- ment of sequences of cassette introns in nxf1 genes in vertebrates has revealed four evolutionarily con- served sequences: 1) 5’ flanking sequence, 2) a region containing СТЕ (constitutive transport element), 3) third conserved sequence, and 4) 3’ flanking sequence. Introns 5 - 6 of nxf1 in Drosophilidae have no similar conserved sequences. The results of sequence align- ment demonstrate a similarity between cassette in- trons of nxf1 in Drosophilidae in two poly(A) se- quences. The

KW - Nxf

KW - Intron Retention

KW - CTE

KW - Poly(A)

KW - Drosophila

KW - Vertebrates

U2 - 10.4236/ojgen.2013.33018

DO - 10.4236/ojgen.2013.33018

M3 - Article

SP - 159

EP - 170

JO - Open Journal of Genetics

JF - Open Journal of Genetics

SN - 2162-4453

IS - 3

ER -

ID: 5642025