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Evidence for neurogenesis in the adult mammalian substantia nigra. / Zhao, Ming; Momma, Stefan; Delfani, Kioumars; Carlén, Marie; Cassidy, Robert M.; Johansson, Clas B.; Brismar, Hjalmar; Shupliakov, Oleg; Frisén, Jonas; Janson, Ann Marie.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 13, 24.06.2003, p. 7925-7930.

Research output: Contribution to journal › Article › peer-review

Harvard

Zhao, M, Momma, S, Delfani, K, Carlén, M, Cassidy, RM, Johansson, CB, Brismar, H, Shupliakov, O, Frisén, J & Janson, AM 2003, 'Evidence for neurogenesis in the adult mammalian substantia nigra', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 13, pp. 7925-7930. https://doi.org/10.1073/pnas.1131955100

APA

Zhao, M., Momma, S., Delfani, K., Carlén, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisén, J., & Janson, A. M. (2003). Evidence for neurogenesis in the adult mammalian substantia nigra. Proceedings of the National Academy of Sciences of the United States of America, 100(13), 7925-7930. https://doi.org/10.1073/pnas.1131955100

Vancouver

Zhao M, Momma S, Delfani K, Carlén M, Cassidy RM, Johansson CB et al. Evidence for neurogenesis in the adult mammalian substantia nigra. Proceedings of the National Academy of Sciences of the United States of America. 2003 Jun 24;100(13):7925-7930. https://doi.org/10.1073/pnas.1131955100

Author

Zhao, Ming ; Momma, Stefan ; Delfani, Kioumars ; Carlén, Marie ; Cassidy, Robert M. ; Johansson, Clas B. ; Brismar, Hjalmar ; Shupliakov, Oleg ; Frisén, Jonas ; Janson, Ann Marie. / Evidence for neurogenesis in the adult mammalian substantia nigra. In: Proceedings of the National Academy of Sciences of the United States of America. 2003 ; Vol. 100, No. 13. pp. 7925-7930.

BibTeX

@article{61b0e4ec957446ffa29ee9ccb85b4a47,
title = "Evidence for neurogenesis in the adult mammalian substantia nigra",
abstract = "New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion. The number of new neurons generated under physiological conditions in substantia nigra pars compacta was found to be several orders of magnitude smaller than in the granular cell layer of the dentate gyrus of the hippocampus. However, if the rate of neuronal turnover is constant, the entire population of dopaminergic neurons in substantia nigra could be replaced during the lifespan of a mouse. These data indicate that neurogenesis in the adult brain is more widespread than previously thought and may have implications for our understanding of the pathogenesis and treatment of neurodegenerative disorders such as Parkinson's disease.",
author = "Ming Zhao and Stefan Momma and Kioumars Delfani and Marie Carl{\'e}n and Cassidy, {Robert M.} and Johansson, {Clas B.} and Hjalmar Brismar and Oleg Shupliakov and Jonas Fris{\'e}n and Janson, {Ann Marie}",
year = "2003",
month = jun,
day = "24",
doi = "10.1073/pnas.1131955100",
language = "English",
volume = "100",
pages = "7925--7930",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "13",

}

RIS

TY - JOUR

T1 - Evidence for neurogenesis in the adult mammalian substantia nigra

AU - Zhao, Ming

AU - Momma, Stefan

AU - Delfani, Kioumars

AU - Carlén, Marie

AU - Cassidy, Robert M.

AU - Johansson, Clas B.

AU - Brismar, Hjalmar

AU - Shupliakov, Oleg

AU - Frisén, Jonas

AU - Janson, Ann Marie

PY - 2003/6/24

Y1 - 2003/6/24

N2 - New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion. The number of new neurons generated under physiological conditions in substantia nigra pars compacta was found to be several orders of magnitude smaller than in the granular cell layer of the dentate gyrus of the hippocampus. However, if the rate of neuronal turnover is constant, the entire population of dopaminergic neurons in substantia nigra could be replaced during the lifespan of a mouse. These data indicate that neurogenesis in the adult brain is more widespread than previously thought and may have implications for our understanding of the pathogenesis and treatment of neurodegenerative disorders such as Parkinson's disease.

AB - New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion. The number of new neurons generated under physiological conditions in substantia nigra pars compacta was found to be several orders of magnitude smaller than in the granular cell layer of the dentate gyrus of the hippocampus. However, if the rate of neuronal turnover is constant, the entire population of dopaminergic neurons in substantia nigra could be replaced during the lifespan of a mouse. These data indicate that neurogenesis in the adult brain is more widespread than previously thought and may have implications for our understanding of the pathogenesis and treatment of neurodegenerative disorders such as Parkinson's disease.

UR - http://www.scopus.com/inward/record.url?scp=0038037721&partnerID=8YFLogxK

U2 - 10.1073/pnas.1131955100

DO - 10.1073/pnas.1131955100

M3 - Article

C2 - 12792021

AN - SCOPUS:0038037721

VL - 100

SP - 7925

EP - 7930

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 13

ER -

ID: 40833237