Evaluation of composition effects on the tissue-adhesive, mechanical and physical properties of physically crosslinked hydrogels based on chitosan and pullulan for wound healing applications

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Evaluation of composition effects on the tissue-adhesive, mechanical and physical properties of physically crosslinked hydrogels based on chitosan and pullulan for wound healing applications. / Elangwe, C.N.; Morozkina, S.N.; Podshivalov, A.V.; Uspenskaya, M.V.

In: International Journal of Biological Macromolecules, Vol. 276, 01.09.2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{62a01ed6c21346d7a4ccca5b38ee543c,

title = "Evaluation of composition effects on the tissue-adhesive, mechanical and physical properties of physically crosslinked hydrogels based on chitosan and pullulan for wound healing applications",

abstract = "Tissue adhesion of hydrogels plays an important role in wound healing, which can improve the efficiency of wound treatment, stop bleeding, facilitate tissue growth and wound closure. However, most non-covalent crosslinked hydrogels have weak tissue adhesion and rheological properties. Furthermore, it remains a challenge to synthesize a fully physically crosslinked hydrogel with good rheological properties without compromising its tissue adhesion strength. In this paper, a physically crosslinked hydrogel was developed from a mixture of chitosan and pullulan in different polymer volume ratios using aqueous NaOH. Fourier transform infrared spectroscopy, scanning electron microscopy, thermal analysis, rheological and lap shear tests were used to evaluate the influence of polymer volume ratios on the rheological, and tissue adhesive properties of the hydrogels. It was found that the hydrogels possessed high tissue adhesive strength ranging from 18.0 ± 0.90 to 49.0 ± 2.45 kPa and good storage moduli up to 5.157 ± 1.062 kPa. Gentamicin was incorporated into this polymer matrix and the release profile was investigated. The ratio of chitosan and pullulan to obtain hydrogels with optimum viscoelastic and tissue adhesive properties was identified to be CS/PUL 2:1. These results indicated that the synthesized hydrogels can be potential materials for biomedical applications such as medical adhesives and wound dressings. {\textcopyright} 2024 Elsevier B.V.",

keywords = "Chitosan, gentamicin, Hydrogels, Tissue-adhesion, Adhesion, Adhesives, Biomaterials, Fourier transform infrared spectroscopy, Medical applications, Rheology, Scanning electron microscopy, Sodium hydroxide, Thermoanalysis, Adhesive properties, Cross-linked hydrogels, Mechanical and physical properties, Pullulans, Rheological property, Tissue adhesion, Tissue adhesives, Volume ratio, Wound healing applications, Chitosan, chitosan, crosslinked hydrogel, gentamicin, hydrogel, pullulan, tissue adhesive, unclassified drug, glucan, Article, biocompatibility, biodegradability, bleeding, body surface, calibration, cell proliferation, chemical reaction kinetics, controlled study, drug delivery system, drug solubility, drug synthesis, dynamic mechanical analysis, dynamics, encapsulation, evaporation, flow kinetics, mechanical properties, nonhuman, outcomes research, physical chemistry, physical properties, polymerization, porosimetry, scanning electron microscopy, static electricity, thermal analysis, thermogravimetry, volatilization, water evaporation, wound healing, chemistry, drug effect, mechanics, Gentamicins, Glucans, Mechanical Phenomena, Spectroscopy, Fourier Transform Infrared, Tissue Adhesives, Wound Healing",

author = "C.N. Elangwe and S.N. Morozkina and A.V. Podshivalov and M.V. Uspenskaya",

note = "Цитирования:3 Export Date: 19 October 2024 CODEN: IJBMD Адрес для корреспонденции: Elangwe, C.N.; Chemical Engineering Center, Kronverskiy Prospekt, 49A, Russian Federation; эл. почта: collinselangwe@gmail.com Химические вещества/CAS: chitosan, 9012-76-4; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; pullulan, 9057-02-7; glucan, 9012-72-0, 9037-91-6; Chitosan; Gentamicins; Glucans; Hydrogels; pullulan; Tissue Adhesives Фирменные наименования: Instron 5966, Instron, United States; JSM-7001F, Jeol, Japan; MCR 502 rheometer, Anton Paar, Austria; Origin Pro software version 2019b; Tensor 37, Bruker, Germany; UNICO 2100 visible spectrophotometer, Unico, United States Производители: Anton Paar, Austria; Bruker, Germany; Jeol, Japan; Instron, United States; Unico, United States",

year = "2024",

month = sep,

day = "1",

doi = "10.1016/j.ijbiomac.2024.133857",

language = "Английский",

volume = "276",

journal = "International Journal of Biological Macromolecules",

issn = "0141-8130",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Evaluation of composition effects on the tissue-adhesive, mechanical and physical properties of physically crosslinked hydrogels based on chitosan and pullulan for wound healing applications

AU - Elangwe, C.N.

AU - Morozkina, S.N.

AU - Podshivalov, A.V.

AU - Uspenskaya, M.V.

N1 - Цитирования:3 Export Date: 19 October 2024 CODEN: IJBMD Адрес для корреспонденции: Elangwe, C.N.; Chemical Engineering Center, Kronverskiy Prospekt, 49A, Russian Federation; эл. почта: collinselangwe@gmail.com Химические вещества/CAS: chitosan, 9012-76-4; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; pullulan, 9057-02-7; glucan, 9012-72-0, 9037-91-6; Chitosan; Gentamicins; Glucans; Hydrogels; pullulan; Tissue Adhesives Фирменные наименования: Instron 5966, Instron, United States; JSM-7001F, Jeol, Japan; MCR 502 rheometer, Anton Paar, Austria; Origin Pro software version 2019b; Tensor 37, Bruker, Germany; UNICO 2100 visible spectrophotometer, Unico, United States Производители: Anton Paar, Austria; Bruker, Germany; Jeol, Japan; Instron, United States; Unico, United States

PY - 2024/9/1

Y1 - 2024/9/1

N2 - Tissue adhesion of hydrogels plays an important role in wound healing, which can improve the efficiency of wound treatment, stop bleeding, facilitate tissue growth and wound closure. However, most non-covalent crosslinked hydrogels have weak tissue adhesion and rheological properties. Furthermore, it remains a challenge to synthesize a fully physically crosslinked hydrogel with good rheological properties without compromising its tissue adhesion strength. In this paper, a physically crosslinked hydrogel was developed from a mixture of chitosan and pullulan in different polymer volume ratios using aqueous NaOH. Fourier transform infrared spectroscopy, scanning electron microscopy, thermal analysis, rheological and lap shear tests were used to evaluate the influence of polymer volume ratios on the rheological, and tissue adhesive properties of the hydrogels. It was found that the hydrogels possessed high tissue adhesive strength ranging from 18.0 ± 0.90 to 49.0 ± 2.45 kPa and good storage moduli up to 5.157 ± 1.062 kPa. Gentamicin was incorporated into this polymer matrix and the release profile was investigated. The ratio of chitosan and pullulan to obtain hydrogels with optimum viscoelastic and tissue adhesive properties was identified to be CS/PUL 2:1. These results indicated that the synthesized hydrogels can be potential materials for biomedical applications such as medical adhesives and wound dressings. © 2024 Elsevier B.V.

AB - Tissue adhesion of hydrogels plays an important role in wound healing, which can improve the efficiency of wound treatment, stop bleeding, facilitate tissue growth and wound closure. However, most non-covalent crosslinked hydrogels have weak tissue adhesion and rheological properties. Furthermore, it remains a challenge to synthesize a fully physically crosslinked hydrogel with good rheological properties without compromising its tissue adhesion strength. In this paper, a physically crosslinked hydrogel was developed from a mixture of chitosan and pullulan in different polymer volume ratios using aqueous NaOH. Fourier transform infrared spectroscopy, scanning electron microscopy, thermal analysis, rheological and lap shear tests were used to evaluate the influence of polymer volume ratios on the rheological, and tissue adhesive properties of the hydrogels. It was found that the hydrogels possessed high tissue adhesive strength ranging from 18.0 ± 0.90 to 49.0 ± 2.45 kPa and good storage moduli up to 5.157 ± 1.062 kPa. Gentamicin was incorporated into this polymer matrix and the release profile was investigated. The ratio of chitosan and pullulan to obtain hydrogels with optimum viscoelastic and tissue adhesive properties was identified to be CS/PUL 2:1. These results indicated that the synthesized hydrogels can be potential materials for biomedical applications such as medical adhesives and wound dressings. © 2024 Elsevier B.V.

KW - Chitosan, gentamicin

KW - Hydrogels

KW - Tissue-adhesion

KW - Adhesion

KW - Adhesives

KW - Biomaterials

KW - Fourier transform infrared spectroscopy

KW - Medical applications

KW - Rheology

KW - Scanning electron microscopy

KW - Sodium hydroxide

KW - Thermoanalysis

KW - Adhesive properties

KW - Cross-linked hydrogels

KW - Mechanical and physical properties

KW - Pullulans

KW - Rheological property

KW - Tissue adhesion

KW - Tissue adhesives

KW - Volume ratio

KW - Wound healing applications

KW - Chitosan

KW - chitosan

KW - crosslinked hydrogel

KW - gentamicin

KW - hydrogel

KW - pullulan

KW - tissue adhesive

KW - unclassified drug

KW - glucan

KW - Article

KW - biocompatibility

KW - biodegradability

KW - bleeding

KW - body surface

KW - calibration

KW - cell proliferation

KW - chemical reaction kinetics

KW - controlled study

KW - drug delivery system

KW - drug solubility

KW - drug synthesis

KW - dynamic mechanical analysis

KW - dynamics

KW - encapsulation

KW - evaporation

KW - flow kinetics

KW - mechanical properties

KW - nonhuman

KW - outcomes research

KW - physical chemistry

KW - physical properties

KW - polymerization

KW - porosimetry

KW - scanning electron microscopy

KW - static electricity

KW - thermal analysis

KW - thermogravimetry

KW - volatilization

KW - water evaporation

KW - wound healing

KW - chemistry

KW - drug effect

KW - mechanics

KW - Gentamicins

KW - Glucans

KW - Mechanical Phenomena

KW - Spectroscopy, Fourier Transform Infrared

KW - Tissue Adhesives

KW - Wound Healing

UR - https://www.mendeley.com/catalogue/912d1217-1a32-3ff6-b346-704f1abadae5/

U2 - 10.1016/j.ijbiomac.2024.133857

DO - 10.1016/j.ijbiomac.2024.133857

M3 - статья

VL - 276

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

SN - 0141-8130

ER -

ID: 126390771