Research output: Contribution to journal › Article › peer-review
Evaluating the Safety of Retrograde Intrarenal Surgery (RIRS) : Intra- and Early Postoperative Complications in Patients Enrolled in the Global Multicentre Flexible Ureteroscopy Outcome Registry (FLEXOR). / Giulioni, Carlo; Fuligni, Demetra; Brocca, Carlo; Ragoori, Deepak; Chew, Ben Chew; Emiliani, Esteban; Heng, Chin Tiong; Tanidir, Yiloren; Gadzhiev, Nariman; Singh, Abhishek; Hamri, Saeed Bin; Soehabali, Boyke; Galosi, Andrea Benedetto; Tailly, Thomas; Traxer, Olivier; Somani, Bhaskar Kumar; Wroclawski, Marcelo L; Gauhar, Vineet; Castellani, Daniele.
In: International braz j urol : official journal of the Brazilian Society of Urology, Vol. 50, No. 4, 2024, p. 459-469.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Evaluating the Safety of Retrograde Intrarenal Surgery (RIRS)
T2 - Intra- and Early Postoperative Complications in Patients Enrolled in the Global Multicentre Flexible Ureteroscopy Outcome Registry (FLEXOR)
AU - Giulioni, Carlo
AU - Fuligni, Demetra
AU - Brocca, Carlo
AU - Ragoori, Deepak
AU - Chew, Ben Chew
AU - Emiliani, Esteban
AU - Heng, Chin Tiong
AU - Tanidir, Yiloren
AU - Gadzhiev, Nariman
AU - Singh, Abhishek
AU - Hamri, Saeed Bin
AU - Soehabali, Boyke
AU - Galosi, Andrea Benedetto
AU - Tailly, Thomas
AU - Traxer, Olivier
AU - Somani, Bhaskar Kumar
AU - Wroclawski, Marcelo L
AU - Gauhar, Vineet
AU - Castellani, Daniele
N1 - Copyright® by the International Brazilian Journal of Urology.
PY - 2024
Y1 - 2024
N2 - PURPOSE: To assess the incidence of the most common intra- and early postoperative complications following RIRS in a large series of patients with kidney stones.METHODS: We conducted a retrospective analysis of patients with kidney stones who underwent RIRS across 21 centers from January 2018 to August 2021, as part of the Global Multicenter Flexible Ureteroscopy Outcome (FLEXOR) Registry.RESULTS: Among 6669 patients undergoing RIRS, 4.5% experienced intraoperative pelvicalyceal system bleeding without necessitating blood transfusion. Only 0.1% of patients, required a blood transfusion. The second most frequent intraoperative complication was ureteric injury due to the ureteral access sheath requiring stenting (1.8% of patients). Postoperatively, the most prevalent early complications were fever/infections requiring antibiotics (6.3%), blood transfusions (5.5%), and sepsis necessitating intensive care unit admission (1.3%). In cases of ureteric injury, a notably higher percentage of patients exhibited multiple stones and stone(s) in the lower pole, and these cases were correlated with prolonged lasing and overall surgical time. Hematuria requiring a blood transfusion was associated with an increased prevalence of larger median maximum stone diameters, particularly among patients with stones exceeding 20 mm. Furthermore, these cases exhibited a significant prolongation in surgical time. Sepsis necessitating admission to the intensive care unit was more prevalent among the elderly, concomitant with a significantly larger median maximum stone diameter.CONCLUSIONS: Our analysis showed that RIRS has a good safety profile but bleeding requiring transfusions, ureteric injury, fever, and sepsis are still the most common complications despite advancements in technology.
AB - PURPOSE: To assess the incidence of the most common intra- and early postoperative complications following RIRS in a large series of patients with kidney stones.METHODS: We conducted a retrospective analysis of patients with kidney stones who underwent RIRS across 21 centers from January 2018 to August 2021, as part of the Global Multicenter Flexible Ureteroscopy Outcome (FLEXOR) Registry.RESULTS: Among 6669 patients undergoing RIRS, 4.5% experienced intraoperative pelvicalyceal system bleeding without necessitating blood transfusion. Only 0.1% of patients, required a blood transfusion. The second most frequent intraoperative complication was ureteric injury due to the ureteral access sheath requiring stenting (1.8% of patients). Postoperatively, the most prevalent early complications were fever/infections requiring antibiotics (6.3%), blood transfusions (5.5%), and sepsis necessitating intensive care unit admission (1.3%). In cases of ureteric injury, a notably higher percentage of patients exhibited multiple stones and stone(s) in the lower pole, and these cases were correlated with prolonged lasing and overall surgical time. Hematuria requiring a blood transfusion was associated with an increased prevalence of larger median maximum stone diameters, particularly among patients with stones exceeding 20 mm. Furthermore, these cases exhibited a significant prolongation in surgical time. Sepsis necessitating admission to the intensive care unit was more prevalent among the elderly, concomitant with a significantly larger median maximum stone diameter.CONCLUSIONS: Our analysis showed that RIRS has a good safety profile but bleeding requiring transfusions, ureteric injury, fever, and sepsis are still the most common complications despite advancements in technology.
KW - Humans
KW - Ureteroscopy/adverse effects
KW - Retrospective Studies
KW - Female
KW - Kidney Calculi/surgery
KW - Male
KW - Postoperative Complications/epidemiology
KW - Middle Aged
KW - Registries
KW - Intraoperative Complications/epidemiology
KW - Aged
KW - Adult
KW - Treatment Outcome
U2 - 10.1590/S1677-5538.IBJU.2024.0055
DO - 10.1590/S1677-5538.IBJU.2024.0055
M3 - Article
C2 - 38743064
VL - 50
SP - 459
EP - 469
JO - International braz j urol : official journal of the Brazilian Society of Urology
JF - International braz j urol : official journal of the Brazilian Society of Urology
SN - 1677-5538
IS - 4
ER -
ID: 135983452